Synonym
ReN-1869; ReN 1869; ReN1869; NNC-05-1869; NNC-051869; NNC 05-1869; NNC051869.
IUPAC/Chemical Name
(R)-1-(3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propyl)-3-piperidine carboxylic acid
InChi Key
RXWDEUWOJGGNHU-HXUWFJFHSA-N
InChi Code
InChI=1S/C24H27NO2/c26-24(27)20-9-5-15-25(17-20)16-6-12-23-21-10-3-1-7-18(21)13-14-19-8-2-4-11-22(19)23/h1-4,7-8,10-12,20H,5-6,9,13-17H2,(H,26,27)/t20-/m1/s1
SMILES Code
O=C([C@H]1CN(CC/C=C2C3=CC=CC=C3CCC4=CC=CC=C\24)CCC1)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
361.49
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Schaffler K, Seibel K, Thomsen M, Edwards M. Effect of the new H1-antagonist
ReN1869 on capsaicin-induced hyperalgesia in human skin/Human phase-I trial using
somatosensory evoked potentials induced by a CO2 laser. Arzneimittelforschung.
2004;54(3):187-91. PubMed PMID: 15112866.
2: Suzuki R, Edwards M, Dickenson AH. ReN-1869
[(R)-1-(3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propyl)-3-piperi
dine carboxylic acid], a novel histamine H1 receptor antagonist, produces potent
and selective antinociceptive effects on dorsal horn neurons after inflammation
and neuropathy. J Pharmacol Exp Ther. 2004 Jun;309(3):1230-8. PubMed PMID:
14988422.
3: Skrumsager BK, Ingwersen SH, Gerrits M. Safety and pharmacokinetics of
ReN1869: a first human dose study in healthy subjects after single-dose
administration. J Clin Pharmacol. 2003 Jan;43(1):66-73. PubMed PMID: 12520630.
4: Olsen UB, Eltorp CT, Ingvardsen BK, Jørgensen TK, Lundbaek JA, Thomsen C,
Hansen AJ. ReN 1869, a novel tricyclic antihistamine, is active against
neurogenic pain and inflammation. Eur J Pharmacol. 2002 Jan 18;435(1):43-57.
PubMed PMID: 11790377.
