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MedKoo Cat#: 412232 | Name: Aspirin calcium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aspirin calcium is the prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)

Chemical Structure

Aspirin calcium
Aspirin calcium
CAS#69-46-5 (calcium)

Theoretical Analysis

MedKoo Cat#: 412232

Name: Aspirin calcium

CAS#: 69-46-5 (calcium)

Chemical Formula: C18H14CaO8

Exact Mass: 398.0315

Molecular Weight: 398.38

Elemental Analysis: C, 54.27; H, 3.54; Ca, 10.06; O, 32.13

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
50-78-2 69-46-5 (calcium) 62952-06-1 (lysine)
Synonym
Aspirin calcium; EINECS200-707-6; EINECS-200-707-6; EINECS 200-707-6
IUPAC/Chemical Name
Benzoic acid, 2-(acetyloxy)-, calcium salt
InChi Key
KRALOLGXHLZTCW-UHFFFAOYSA-L
InChi Code
InChI=1S/2C9H8O4.Ca/c2*1-6(10)13-8-5-3-2-4-7(8)9(11)12;/h2*2-5H,1H3,(H,11,12);/q;;+2/p-2
SMILES Code
O=C([O-])C1=CC=CC=C1OC(C)=O.O=C([O-])C2=CC=CC=C2OC(C)=O.[Ca+2]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 398.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Vynckier P, Ferrannini G, Rydén L, Tokgözoğlu L, Bruthans J, Kotseva K, Wood D, De Backer T, Gevaert S, De Bacquer D, De Smedt D; EUROASPIRE V Investigators group. Medical Treatment in Coronary Patients: Is there Still a Gender Gap? Results from European Society of Cardiology EUROASPIRE V Registry. Cardiovasc Drugs Ther. 2020 Oct 17. doi: 10.1007/s10557-020-07095-6. Epub ahead of print. PMID: 33068226. 2: Nkamba DM, Vangu R, Elongi M, Magee LA, Wembodinga G, Bernard P, Ditekemena J, Robert A. Health facility readiness and provider knowledge as correlates of adequate diagnosis and management of pre-eclampsia in Kinshasa, Democratic Republic of Congo. BMC Health Serv Res. 2020 Oct 7;20(1):926. doi: 10.1186/s12913-020-05795-1. PMID: 33028310; PMCID: PMC7542875. 3: Cardoso R, Dudum R, Ferraro RA, Bittencourt M, Blankstein R, Blaha MJ, Nasir K, Rajagopalan S, Michos ED, Blumenthal RS, Cainzos-Achirica M. Cardiac Computed Tomography for Personalized Management of Patients With Type 2 Diabetes Mellitus. Circ Cardiovasc Imaging. 2020 Sep;13(9):e011365. doi: 10.1161/CIRCIMAGING.120.011365. Epub 2020 Sep 9. PMID: 32900225. 4: Sun LX, Xie YM, Liu H, Li YY, Zhuang Y. [Analysis of clinical application characteristics and drug combination of Ciwujia Injection in 12 554 cases in real world]. Zhongguo Zhong Yao Za Zhi. 2020 Aug;45(15):3505-3510. Chinese. doi: 10.19540/j.cnki.cjcmm.20200428.501. PMID: 32893537. 5: Scott G, Gillon TE, Pels A, von Dadelszen P, Magee LA. Guidelines- similarities and dissimilarities: a systematic review of international clinical practice guidelines for pregnancy hypertension. Am J Obstet Gynecol. 2020 Aug 20:S0002-9378(20)30846-2. doi: 10.1016/j.ajog.2020.08.018. Epub ahead of print. PMID: 32828743. 6: Li W, Ren X, Zhang L. Clinical efficacy of atorvastatin calcium combined with aspirin in patients with acute ischemic stroke and effect on neutrophils, lymphocytes and IL-33. Exp Ther Med. 2020 Aug;20(2):1277-1284. doi: 10.3892/etm.2020.8820. Epub 2020 May 29. PMID: 32765667; PMCID: PMC7388513. 7: Tajada S, Villalobos C. Calcium Permeable Channels in Cancer Hallmarks. Front Pharmacol. 2020 Jul 7;11:968. doi: 10.3389/fphar.2020.00968. PMID: 32733237; PMCID: PMC7358640. 8: Guo XC, Gao Y, Xie YM, Sun LX, Xu HY, Zhuang Y. [Study on clinical characteristics of Danshen Chuanxiongqin Injection in treatment of cerebral infarction in real world]. Zhongguo Zhong Yao Za Zhi. 2020 Jul;45(14):3307-3315. Chinese. doi: 10.19540/j.cnki.cjcmm.20200327.501. PMID: 32726044. 9: Banihani SA, Shatnawi RM. Aspirin decreases human sperm motility and vitality, chelates seminal calcium, but insignificantly reduces seminal nitric oxide production. Andrologia. 2020 Jul 29:e13776. doi: 10.1111/and.13776. Epub ahead of print. PMID: 32725931. 10: Ahmad K, Budoff MJ, Delaney JA, Mao S, Gao Y, Nasir K, Tracy R, Li D. Association of Aspirin and Other Nonsteroidal Anti-inflammatory Drugs With Vertebral Trabecular Bone: Data From Multiethnic Study of Atherosclerosis, a Population-Based Multicenter Cohort Study. J Comput Assist Tomogr. 2020 Jul/Aug;44(4):562-568. doi: 10.1097/RCT.0000000000001022. PMID: 32697527. 11: Magee LA, Khalil A, Kametas N, von Dadelszen P. Toward personalized management of chronic hypertension in pregnancy. Am J Obstet Gynecol. 2020 Jul 18:S0002-9378(20)30745-6. doi: 10.1016/j.ajog.2020.07.026. Epub ahead of print. PMID: 32687817; PMCID: PMC7367795. 12: Yang Y, Song H, Wang B, Tian Q, Li B. A novel di-peptide Met-Glu from collagen hydrolysates inhibits platelet aggregation and thrombus formation via regulation of Gq-mediated signaling. J Food Biochem. 2020 Jul 13:e13352. doi: 10.1111/jfbc.13352. Epub ahead of print. PMID: 32662128. 13: Al-Musawe L, Torre C, Guerreiro JP, Rodrigues AT, Raposo JF, Mota-Filipe H, Martins AP. Polypharmacy, potentially serious clinically relevant drug-drug interactions, and inappropriate medicines in elderly people with type 2 diabetes and their impact on quality of life. Pharmacol Res Perspect. 2020 Aug;8(4):e00621. doi: 10.1002/prp2.621. PMID: 32618136; PMCID: PMC7332581. 14: Griffith RJ, Alsweiler J, Moore AE, Brown S, Middleton P, Shepherd E, Crowther CA. Interventions to prevent women from developing gestational diabetes mellitus: an overview of Cochrane Reviews. Cochrane Database Syst Rev. 2020 Jun 11;6(6):CD012394. doi: 10.1002/14651858.CD012394.pub3. PMID: 32526091; PMCID: PMC7388385. 15: Santucci A, Riccini C, Cavallini C. Treatment of stable ischaemic heart disease: the old and the new. Eur Heart J Suppl. 2020 Jun;22(Suppl E):E54-E59. doi: 10.1093/eurheartj/suaa060. Epub 2020 Mar 29. PMID: 32523440; PMCID: PMC7270915. 16: Ayodele OO, Onajobi FD, Osoniyi OR. Modulation of Blood Coagulation and Hematological Parameters by Crassocephalum crepidioides Leaf Methanol Extract and Fractions in STZ-Induced Diabetes in the Rat. ScientificWorldJournal. 2020 May 15;2020:1036364. doi: 10.1155/2020/1036364. PMID: 32508536; PMCID: PMC7245657. 17: Rezende GP, Casagrande L, Guida JPS, Parpinelli MA, Surita FG, Costa ML. Maternal and Perinatal Outcomes of Pregnancies Complicated by Chronic Hypertension Followed at a Referral Hospital. Rev Bras Ginecol Obstet. 2020 May;42(5):248-254. English. doi: 10.1055/s-0040-1709190. Epub 2020 May 29. PMID: 32483805. 18: Zhao M, Woodward M, Vaartjes I, Millett ERC, Klipstein-Grobusch K, Hyun K, Carcel C, Peters SAE. Sex Differences in Cardiovascular Medication Prescription in Primary Care: A Systematic Review and Meta-Analysis. J Am Heart Assoc. 2020 Jun 2;9(11):e014742. doi: 10.1161/JAHA.119.014742. Epub 2020 May 20. PMID: 32431190; PMCID: PMC7429003. 19: Gatford KL, Andraweera PH, Roberts CT, Care AS. Animal Models of Preeclampsia: Causes, Consequences, and Interventions. Hypertension. 2020 Jun;75(6):1363-1381. doi: 10.1161/HYPERTENSIONAHA.119.14598. Epub 2020 Apr 6. PMID: 32248704. 20: Cainzos-Achirica M, Miedema MD, McEvoy JW, Al Rifai M, Greenland P, Dardari Z, Budoff M, Blumenthal RS, Yeboah J, Duprez DA, Mortensen MB, Dzaye O, Hong J, Nasir K, Blaha MJ. Coronary Artery Calcium for Personalized Allocation of Aspirin in Primary Prevention of Cardiovascular Disease in 2019: The MESA Study (Multi-Ethnic Study of Atherosclerosis). Circulation. 2020 May 12;141(19):1541-1553. doi: 10.1161/CIRCULATIONAHA.119.045010. Epub 2020 Apr 1. PMID: 32233663; PMCID: PMC7217722.