Synonym
YM-26734; YM26734; YM 26734
IUPAC/Chemical Name
1,1'-[5-[3,4-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-1-dodecanone
InChi Key
CEJAYJCUSZHYDS-UHFFFAOYSA-N
InChi Code
InChI=1S/C45H62O8/c1-3-5-7-9-11-13-15-17-19-21-36(48)41-43(50)40(44(51)42(45(41)52)37(49)22-20-18-16-14-12-10-8-6-4-2)35-30-38(31-23-25-32(46)26-24-31)53-39-29-33(47)27-28-34(35)39/h23-29,35,38,46-47,50-52H,3-22,30H2,1-2H3
SMILES Code
OC(C=C1)=CC2=C1C(C3=C(O)C(C(CCCCCCCCCCC)=O)=C(O)C(C(CCCCCCCCCCC)=O)=C3O)CC(C4=CC=C(O)C=C4)O2
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
730.98
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Murakami, M., Taketomi, Y., Miki, Y., et al. Recent progress in phospholipase A2 research: From cells to animals to humans. Progress in Lipid Research 50(2), 152-192 (2011).
2. Murakami, M., Taketomi, Y., Girard, C., et al. Emerging roles of secreted phospholipase A2 enzymes: Lessons from transgenic and knockout mice. Biochimie 92(6), 561-582 (2010).
3. Miyake, A., Yamamoto, H., Kubota, E., et al. Suppression of inflammatory responses to 12-O-tetradecanoyl-phorbol-13-acetate and carrageenin by YM-26734, a selective inhibitor of extracellular group II phospholipase A2. British Journal of Pharmacology 110, 447-453 (1993).
4. Oslund, R.C., Cermak, N., Verlinde, C.L.M.J., et al. Simplified YM-26734 inhibitors of secreted phospholipase A2 group IIA. Bioorganic & Medicinal Chemistry Letters 18(20), 5415-5419 (2008).
5. Lambeau, G., and Gelb, M.H. Biochemistry and physiology of mammalian secreted phospholipases A2. Annual Reviews of Biochemistry 77, 495-520 (2008).
