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MedKoo Cat#: 463187 | Name: Penicillic acid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Penicillic acid is a mycotoxin with antibiotic and carcinogenic activity.

Chemical Structure

Penicillic acid
Penicillic acid
CAS#90-65-3

Theoretical Analysis

MedKoo Cat#: 463187

Name: Penicillic acid

CAS#: 90-65-3

Chemical Formula: C8H10O4

Exact Mass: 170.0579

Molecular Weight: 170.16

Elemental Analysis: C, 56.47; H, 5.92; O, 37.61

Price and Availability

Size Price Availability Quantity
10mg USD 450.00 2 Weeks
25mg USD 700.00 2 Weeks
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Related CAS #
No Data
Synonym
Penicillic acid;
IUPAC/Chemical Name
(Z)-3-methoxy-5-methyl-4-oxohexa-2,5-dienoic acid
InChi Key
VOUGEZYPVGAPBB-XQRVVYSFSA-N
InChi Code
InChI=1S/C8H10O4/c1-5(2)8(11)6(12-3)4-7(9)10/h4H,1H2,2-3H3,(H,9,10)/b6-4-
SMILES Code
C=C(C)C(/C(OC)=C/C(O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 170.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Onodera T, Momose I, Adachi H, Yamazaki Y, Sawa R, Ohba SI, Kawada M. Human pancreatic cancer cells under nutrient deprivation are vulnerable to redox system inhibition. J Biol Chem. 2020 Sep 25:jbc.RA120.013893. doi: 10.1074/jbc.RA120.013893. Epub ahead of print. PMID: 32978257. 2: Luciano-Rosario D, Keller NP, Jurick WM 2nd. Penicillium expansum: biology, omics, and management tools for a global postharvest pathogen causing blue mould of pome fruit. Mol Plant Pathol. 2020 Nov;21(11):1391-1404. doi: 10.1111/mpp.12990. Epub 2020 Sep 23. PMID: 32969130; PMCID: PMC7548999. 3: Hu HC, Li CY, Tsai YH, Yang DY, Wu YC, Hwang TL, Chen SL, Fülöp F, Hunyadi A, Yen CH, Cheng YB, Chang FR. Secondary Metabolites and Bioactivities of Aspergillus ochraceopetaliformis Isolated from Anthurium brownii. ACS Omega. 2020 Aug 14;5(33):20991-20999. doi: 10.1021/acsomega.0c02489. PMID: 32875235; PMCID: PMC7450643. 4: Stoev SD. Long term preliminary studies on toxic and carcinogenic effect of individual or simultaneous exposure to ochratoxin A and penicillic acid in mice. Toxicon. 2020 Sep;184:192-201. doi: 10.1016/j.toxicon.2020.06.013. Epub 2020 Jun 20. PMID: 32569847. 5: Ling S, Li X, Zhao Q, Wang R, Tan T, Wang S. Preparation of monoclonal antibody against penicillic acid (PA) and its application in the immunological detection. Food Chem. 2020 Jul 30;319:126505. doi: 10.1016/j.foodchem.2020.126505. Epub 2020 Feb 27. PMID: 32169762. 6: Aldholmi M, Wilkinson B, Ganesan A. Epigenetic modulation of secondary metabolite profiles in Aspergillus calidoustus and Aspergillus westerdijkiae through histone deacetylase (HDAC) inhibition by vorinostat. J Antibiot (Tokyo). 2020 Jun;73(6):410-413. doi: 10.1038/s41429-020-0286-5. Epub 2020 Feb 14. PMID: 32060485. 7: Liang J, Dong Y, Yuan X, Fan L, Zhao S, Wang L. Fast determination of 14 mycotoxins in chestnut by dispersive solid-phase extraction coupled with ultra high performance liquid chromatography-tandem mass spectrometry. J Sep Sci. 2019 Jul;42(13):2191-2201. doi: 10.1002/jssc.201900050. PMID: 31012251. 8: Frank M, Özkaya FC, Müller WEG, Hamacher A, Kassack MU, Lin W, Liu Z, Proksch P. Cryptic Secondary Metabolites from the Sponge-Associated Fungus Aspergillus ochraceus. Mar Drugs. 2019 Feb 3;17(2):99. doi: 10.3390/md17020099. PMID: 30717441; PMCID: PMC6410417. 9: Mirzaei R, Mesdaghinia A, Hoseini SS, Yunesian M. Antibiotics in urban wastewater and rivers of Tehran, Iran: Consumption, mass load, occurrence, and ecological risk. Chemosphere. 2019 Apr;221:55-66. doi: 10.1016/j.chemosphere.2018.12.187. Epub 2018 Dec 27. PMID: 30634149. 10: Zhang B, Chen X, Han SY, Li M, Ma TZ, Sheng WJ, Zhu X. Simultaneous Analysis of 20 Mycotoxins in Grapes and Wines from Hexi Corridor Region (China): Based on a QuEChERS⁻UHPLC⁻MS/MS Method. Molecules. 2018 Aug 2;23(8):1926. doi: 10.3390/molecules23081926. PMID: 30072592; PMCID: PMC6222325. 11: Casquete R, Rodríguez A, Hernández A, Martín A, Bartolomé T, Córdoba JJ, Córdoba MG. Occurrence of Toxigenic Fungi and Mycotoxins during Smoked Paprika Production. J Food Prot. 2017 Dec;80(12):2068-2077. doi: 10.4315/0362-028X.JFP-17-164. PMID: 29154716. 12: Kim JA, Jeon J, Park SY, Kim KT, Choi G, Nguyen HT, Jeon SJ, Lee HB, Bae CH, Yang HS, Yeo JH, Kim JC, Lee YH, Kim S. Draft Genome Sequence of Aspergillus persii NIBRFGC000004109, Which Has Antibacterial Activity against Plant- Pathogenic Bacteria. Genome Announc. 2017 Sep 21;5(38):e00932-17. doi: 10.1128/genomeA.00932-17. PMID: 28935731; PMCID: PMC5609410. 13: Wei D, Wang Y, Jiang D, Feng X, Li J, Wang M. Survey of Alternaria Toxins and Other Mycotoxins in Dried Fruits in China. Toxins (Basel). 2017 Jun 26;9(7):200. doi: 10.3390/toxins9070200. PMID: 28672847; PMCID: PMC5535147. 14: Guijarro B, Larena I, Melgarejo P, De Cal A. Adaptive conditions and safety of the application of Penicillium frequentans as a biocontrol agent on stone fruit. Int J Food Microbiol. 2017 Aug 2;254:25-35. doi: 10.1016/j.ijfoodmicro.2017.05.004. Epub 2017 May 8. PMID: 28511111. 15: Phainuphong P, Rukachaisirikul V, Tadpetch K, Sukpondma Y, Saithong S, Phongpaichit S, Preedanon S, Sakayaroj J. γ-Butenolide and furanone derivatives from the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178. Phytochemistry. 2017 May;137:165-173. doi: 10.1016/j.phytochem.2017.02.008. Epub 2017 Feb 20. PMID: 28228227. 16: Oh SY, Cedergreen N, Yiannikouris A, Swamy HV, Karrow NA. Assessing interactions of binary mixtures of Penicillium mycotoxins (PMs) by using a bovine macrophage cell line (BoMacs). Toxicol Appl Pharmacol. 2017 Mar 1;318:33-40. doi: 10.1016/j.taap.2017.01.015. Epub 2017 Jan 24. PMID: 28130037. 17: Qin X, Sun Q, Yang B, Pan X, He Y, Yang H. Quorum sensing influences phage infection efficiency via affecting cell population and physiological state. J Basic Microbiol. 2017 Feb;57(2):162-170. doi: 10.1002/jobm.201600510. Epub 2016 Oct 7. PMID: 27714824. 18: Svingen T, Lund Hansen N, Taxvig C, Vinggaard AM, Jensen U, Have Rasmussen P. Enniatin B and beauvericin are common in Danish cereals and show high hepatotoxicity on a high-content imaging platform. Environ Toxicol. 2017 May;32(5):1658-1664. doi: 10.1002/tox.22367. Epub 2016 Sep 15. PMID: 27628925. 19: Hallas-Møller M, Nielsen KF, Frisvad JC. Production of the Fusarium Mycotoxin Moniliformin by Penicillium melanoconidium. J Agric Food Chem. 2016 Jun 8;64(22):4505-10. doi: 10.1021/acs.jafc.6b00298. Epub 2016 May 31. PMID: 27195914. 20: Nguyen HT, Yu NH, Jeon SJ, Lee HW, Bae CH, Yeo JH, Lee HB, Kim IS, Park HW, Kim JC. Antibacterial activities of penicillic acid isolated from Aspergillus persii against various plant pathogenic bacteria. Lett Appl Microbiol. 2016 Jun;62(6):488-93. doi: 10.1111/lam.12578. PMID: 27105128.

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