IUPAC/Chemical Name
3,6-dibromo-α-[(dimethylamino)methyl]-9H-carbazole-9-ethanol
InChi Key
XUBJEDZHBUPBKL-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H18Br2N2O/c1-20(2)9-13(22)10-21-16-5-3-11(18)7-14(16)15-8-12(19)4-6-17(15)21/h3-8,13,22H,9-10H2,1-2H3
SMILES Code
OC(CN(C)C)CN1C2=CC=C(Br)C=C2C3=C1C=CC(Br)=C3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
426.15
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2. Peterson, J.R., Bickford, L.C., Morgan, D., et al. Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nature Structural & Molecular Biology 11(8), 747-755 (2004).
3. Guerriero, C.J., and Weisz, O.A. N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels. American Journal of Physiology.Cell Physiology 292(4), C1562-C1566 (2007).
4. Welliver, T.P., Chang, S.L., Linderman, J.J., et al. Ruffles limit diffusion in the plasma membrane during macropinosome formation. Journal of Cell Science 124(23), 4106-4114 (2011).
5. Wegner, A.M., Nebhan, C.A., Hu, L., et al. N-WASP and the Arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses. The Journal of Biological Chemisty 283(23), 15912-15920 (2008).
