MedKoo Cat#: 412198 | Name: Benzydamine free base
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Benzydamine (free base) is a benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects. It is used to reduce post-surgical and post-traumatic pain and edema and to promote healing. It is also used topically in treatment of RHEUMATIC DISEASES and INFLAMMATION of the mouth and throat.

Chemical Structure

Benzydamine free base
CAS#642-72-8 (free base)

Theoretical Analysis

MedKoo Cat#: 412198

Name: Benzydamine free base

CAS#: 642-72-8 (free base)

Chemical Formula: C19H23N3O

Exact Mass: 309.1841

Molecular Weight: 309.41

Elemental Analysis: C, 73.76; H, 7.49; N, 13.58; O, 5.17

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
10mg USD 800.00 2 Weeks
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Synonym
Benzydamine free base; C1523; C-1523; C 1523
IUPAC/Chemical Name
1-Propanamine, N,N-dimethyl-3-((1-(phenylmethyl)-1H-indazol-3-yl)oxy)-
InChi Key
CNBGNNVCVSKAQZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H23N3O/c1-21(2)13-8-14-23-19-17-11-6-7-12-18(17)22(20-19)15-16-9-4-3-5-10-16/h3-7,9-12H,8,13-15H2,1-2H3
SMILES Code
CN(C)CCCOC1=NN(CC2=CC=CC=C2)C3=C1C=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 309.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PMID: 32820466. 4: Alves TFR, Rios AC, da Silva Pontes K, Portella DL, Aranha N, Severino P, Souto EB, Gonsalves JKM, de Souza Nunes R, Chaud MV. Bilayer Mucoadhesive Buccal Film for Mucosal Ulcers Treatment: Development, Characterization, and Single Study Case. Pharmaceutics. 2020 Jul 11;12(7):657. doi: 10.3390/pharmaceutics12070657. PMID: 32664574; PMCID: PMC7408552. 5: Ahmed MG, Adinarayana S. Formulation Design of Hydrocortisone Films for the Treatment of Aphthous Ulcers. Turk J Pharm Sci. 2019 Sep;16(3):348-355. doi: 10.4274/tjps.galenos.2018.75046. Epub 2019 Jul 10. PMID: 32454734; PMCID: PMC7227952. 6: Surboyo MDC, Mahdani FY, Ernawati DS, Sarasati A, Rezkita F. The Macrophage Responses during Diabetic Oral Ulcer Healing by Liquid Coconut Shell Smoke: An Immunohistochemical Analysis. Eur J Dent. 2020 Jul;14(3):410-414. doi: 10.1055/s-0040-1712776. Epub 2020 May 24. PMID: 32447753; PMCID: PMC7440958. 7: Sugiarto A, Kapuangan C, Tantri AR, Chrisnata V. Effectivity of benzydamine hydrochloride gargle to reduce propofol consumption in endoscopic retrograde cholangiopancreatography procedure: a randomized controlled trial. BMC Anesthesiol. 2020 May 23;20(1):123. doi: 10.1186/s12871-020-00996-x. PMID: 32446304; PMCID: PMC7245039. 8: Di Stefano AFD, Radicioni MM, Vaccani A, Caccia G, Focanti F, Salvatori E, Pelacchi F, Picollo R, Rosignoli MT, Olivieri S, Bovi G, Comandini A. Phase I Study in Healthy Women of a Novel Antimycotic Vaginal Ovule Combining Econazole and Benzydamine. Infect Dis Obstet Gynecol. 2020 May 2;2020:7201840. doi: 10.1155/2020/7201840. PMID: 32410819; PMCID: PMC7212273. 9: Zhang X, Sun D, Qin N, Liu M, Zhang J, Li X. Comparative prevention potential of 10 mouthwashes on intolerable oral mucositis in cancer patients: A Bayesian network analysis. Oral Oncol. 2020 Aug;107:104751. doi: 10.1016/j.oraloncology.2020.104751. Epub 2020 May 7. PMID: 32388411. 10: Yu YY, Deng JL, Jin XR, Zhang ZZ, Zhang XH, Zhou X. Effects of 9 oral care solutions on the prevention of oral mucositis: a network meta-analysis of randomized controlled trials. Medicine (Baltimore). 2020 Apr;99(16):e19661. doi: 10.1097/MD.0000000000019661. PMID: 32311938; PMCID: PMC7220734. 11: Yhim HB, Yoon SH, Jang YE, Lee JH, Kim EH, Kim JT, Kim HS. Effects of benzydamine hydrochloride on postoperative sore throat after extubation in children: a randomized controlled trial. BMC Anesthesiol. 2020 Apr 4;20(1):77. doi: 10.1186/s12871-020-00995-y. PMID: 32247315; PMCID: PMC7126164. 12: Romita P, Barlusconi C, Mercurio CS, Hansel K, Stingeni L, Foti C. Photoallergic contact cheilitis from benzydamine hydrochloride contained in a mouthwash. Contact Dermatitis. 2020 Aug;83(2):130-132. doi: 10.1111/cod.13541. Epub 2020 Apr 27. PMID: 32232858. 13: Alaiye A, Kaya E, Pınarbaşlı MÖ, Harmancı N, Yıldırım C, Dönmez DB, Cingi C. An Experimental Comparison of the Analgesic and Anti-Inflammatory Effects of Safflower Oil, Benzydamine HCl, and Naproxen Sodium. J Med Food. 2020 Aug;23(8):862-869. doi: 10.1089/jmf.2019.0157. Epub 2020 Mar 27. PMID: 32216647. 14: Son HS, Lee J, Lee HI, Kim N, Jo YJ, Lee GR, Hong SE, Kwon M, Kim NY, Kim HJ, Park JH, Lee SY, Jeong W. Benzydamine inhibits osteoclast differentiation and bone resorption via down-regulation of interleukin-1 β expression. Acta Pharm Sin B. 2020 Mar;10(3):462-474. doi: 10.1016/j.apsb.2019.11.004. Epub 2019 Nov 8. PMID: 32140392; PMCID: PMC7049613. 15: Brennan PA, Lewthwaite R, Sakthithasan P, McGuigan S, Donnelly O, Alam P, Gomez RS, Fedele S. Diclofenac Mouthwash as a potential therapy for reducing pain and discomfort in chemo-radiotherapy-induced oral mucositis. J Oral Pathol Med. 2020 Oct;49(9):956-959. doi: 10.1111/jop.13001. Epub 2020 Mar 10. PMID: 32017243. 16: Cassano R, Curcio F, Mandracchia D, Trapani A, Trombino S. Gelatin and Glycerine-Based Bioadhesive Vaginal Hydrogel. Curr Drug Deliv. 2020;17(4):303-311. doi: 10.2174/1567201817666200129130031. PMID: 31995006. 17: Alalwani A, Buhara O, Tüzüm MŞ. Oral Health-Related Quality of Life and the Use of Oral and Topical Nonsteroidal Anti-Inflammatory Drugs for Pericoronitis. Med Sci Monit. 2019 Dec 3;25:9200-9206. doi: 10.12659/MSM.918085. PMID: 31860632; PMCID: PMC6909906. 18: Altinsoy S, Ütebey G, Kavak Akelma F, Ergil J. The effects of topical chlorhexidine-benzydamine spray on laryngeal mask airway application. Minerva Anestesiol. 2020 Mar;86(3):277-285. doi: 10.23736/S0375-9393.19.13970-3. Epub 2019 Dec 6. PMID: 31818083. 19: Vural Ç, Yurttutan ME, Sancak KT, Tüzüner AM. Effect of chlorhexidine/benzydamine soaked pharyngeal packing on throat pain and postoperative nausea & vomiting in orthognathic surgery. J Craniomaxillofac Surg. 2019 Dec;47(12):1861-1867. doi: 10.1016/j.jcms.2019.11.014. Epub 2019 Nov 29. 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