ZXH-1-161 is a novel Selective Degrader of GSPT1. Due to its potency and selectivity for GSPT1, ZXH-1-161 is a superior tool to CC-885 for exploring the therapeutic potential of GSPT1 degradation and may provide additional opportunities for therapeutically targeting GSPT1, where a degradation-based strategy has already shown potential in the treatment of acute myeloid leukemia (AML).
MedKoo Cat#: 463152
Name: ZXH-1-161 free base
CAS#: 2407654-51-5 (free base)
Chemical Formula: C26H24N6O3
Exact Mass: 468.1910
Molecular Weight: 468.52
Elemental Analysis: C, 66.65; H, 5.16; N, 17.94; O, 10.24
The following data is based on the product molecular weight 468.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
