MedKoo Cat#: 412121 | Name: Chlorpromazine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chlorpromazine is an antipsychotic medication. It is primarily used to treat psychotic disorders such as schizophrenia. Other uses include the treatment of bipolar disorder, severe behavioral problems in children including those with attention deficit hyperactivity disorder, nausea and vomiting, anxiety before surgery, and hiccups that do not improve following other measures. It can be given by mouth, by injection into a muscle, or into a vein.

Chemical Structure

Chlorpromazine
Chlorpromazine
CAS#50-53-3 (free)

Theoretical Analysis

MedKoo Cat#: 412121

Name: Chlorpromazine

CAS#: 50-53-3 (free)

Chemical Formula: C17H19ClN2S

Exact Mass: 318.0957

Molecular Weight: 318.86

Elemental Analysis: C, 64.04; H, 6.01; Cl, 11.12; N, 8.79; S, 10.05

Price and Availability

Size Price Availability Quantity
1g USD 350.00 2 Weeks
2g USD 550.00 2 Weeks
5g USD 1,050.00 2 Weeks
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Synonym
Chlorpromazine; BC-135; BC135; BC 135
IUPAC/Chemical Name
10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-
InChi Key
ZPEIMTDSQAKGNT-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
SMILES Code
CN(C)CCCN1C2=C(C=CC=C2)SC3=CC=C(Cl)C=C13
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 318.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PMID: 33005869; PMCID: PMC7523622. 4: Gerhard T, Stroup TS, Correll CU, Setoguchi S, Strom BL, Huang C, Tan Z, Crystal S, Olfson M. Mortality risk of antipsychotic augmentation for adult depression. PLoS One. 2020 Sep 30;15(9):e0239206. doi: 10.1371/journal.pone.0239206. PMID: 32997687; PMCID: PMC7526884. 5: Toro C, Shirvan L, Tifft C. HEXA Disorders. 1999 Mar 11 [updated 2020 Oct 1]. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2020. PMID: 20301397. 6: Cronqvist T, Erlandsson L, Tannetta D, Hansson SR. Placental syncytiotrophoblast extracellular vesicles enter primary endothelial cells through clathrin-mediated endocytosis. Placenta. 2020 Oct;100:133-141. doi: 10.1016/j.placenta.2020.07.006. Epub 2020 Jul 11. PMID: 32980046. 7: Ruiz Yanzi MA, Goicochea MT, Yorio F, Alessandro L, Farez MF, Marrodan M. Intravenous Chlorpromazine as Potentially Useful Treatment for Chronic Headache Disorders. Headache. 2020 Sep 26. doi: 10.1111/head.13976. Epub ahead of print. PMID: 32979239. 8: Gareri P, Gallelli L, Cotroneo AM, Manfredi VGL, De Sarro G. The Art of Safe and Judicious Deprescribing in an Elderly Patient: A Case Report. Geriatrics (Basel). 2020 Sep 21;5(3):E57. doi: 10.3390/geriatrics5030057. PMID: 32967254. 9: Opeyemi A, Adeoye O, Adebanji A, Olawumi J. CREM, PRM I and II gene expression in Wistar rats testes treated with antipsychotic drugs: Chlorpromazine, Rauwolfia vomitoria and co-administration of reserpine, zinc and ascorbic acid. JBRA Assist Reprod. 2020 Sep 1. doi: 10.5935/1518-0557.20200058. Epub ahead of print. PMID: 32960520. 10: Atama CI, Nnaji EC, Christian Ezeoyili I, Udeani FO, Onovo CJ, Ike Ossai N, Oscar Aguzie I, Nwani CD. Neuromodulatory and oxidative stress evaluations in African catfish Clarias gariepinus exposed to antipsychotic drug chlorpromazine. Drug Chem Toxicol. 2020 Sep 22:1-7. doi: 10.1080/01480545.2020.1822391. Epub ahead of print. PMID: 32957809. 11: Otręba M, Kośmider L, Rzepecka-Stojko A. Antiviral activity of chlorpromazine, fluphenazine, perphenazine, prochlorperazine, and thioridazine towards RNA-viruses. A review. Eur J Pharmacol. 2020 Sep 16;887:173553. doi: 10.1016/j.ejphar.2020.173553. Epub ahead of print. PMID: 32949606; PMCID: PMC7493736. 12: Gao RL, Lim KS, Luthra AS. Discontinuation of antipsychotics treatment for elderly patients within a specialized behavioural unit: a retrospective review. Int J Clin Pharm. 2020 Sep 10. doi: 10.1007/s11096-020-01135-9. Epub ahead of print. PMID: 32909220. 13: Antoszczak M, Markowska A, Markowska J, Huczyński A. Antidepressants and antipsychotic agents as repurposable oncological drug candidates. Curr Med Chem. 2020 Sep 7. doi: 10.2174/0929867327666200907141452. Epub ahead of print. PMID: 32895037. 14: Jha SK, Chung JY, Pangeni R, Choi HS, Subedi L, Kweon S, Choi JU, Byun Y, Kim YH, Park JW. Enhanced antitumor efficacy of bile acid-lipid complex-anchored docetaxel nanoemulsion via oral metronomic scheduling. J Control Release. 2020 Sep 3;328:368-394. doi: 10.1016/j.jconrel.2020.08.067. Epub ahead of print. PMID: 32890552. 15: Phadungcharoen N, Pengwanput N, Nakapan A, Sutitaphan U, Thanomklom P, Jongudomsombut N, Chinsriwongkul A, Rojanarata T. Ion pair extraction coupled with digital image colorimetry as a rapid and green platform for pharmaceutical analysis: An example of chlorpromazine hydrochloride tablet assay. Talanta. 2020 Nov 1;219:121271. doi: 10.1016/j.talanta.2020.121271. Epub 2020 Jun 13. PMID: 32887161. 16: Wong HJ, Chew QH, Lee RD, Sim K. Illness remission status and commissural and associative brain white matter fiber changes in schizophrenia. Psych J. 2020 Sep 2. doi: 10.1002/pchj.399. Epub ahead of print. PMID: 32881375. 17: GajdÁcs M, NovÉ M, Csonka Á, Varga B, SanmartÍn C, DomÍnguez-Álvarez E, Spengler G. Phenothiazines and Selenocompounds: A Potential Novel Combination Therapy of Multidrug Resistant Cancer. Anticancer Res. 2020 Sep;40(9):4921-4928. doi: 10.21873/anticanres.14495. PMID: 32878780. 18: De Jesus O, Fogwe DT, Mesfin FB, M Das J. Neuromodulation Surgery For Psychiatric Disorders. 2020 Sep 3. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan–. PMID: 29493988. 19: Tukker AM, Wijnolts FMJ, de Groot A, Westerink RHS. Applicability of hiPSC- derived neuronal co-cultures and rodent primary cortical cultures for in vitro seizure liability assessment. Toxicol Sci. 2020 Aug 31:kfaa136. doi: 10.1093/toxsci/kfaa136. Epub ahead of print. PMID: 32866265. 20: Mat Luwi NE, Kadir R, Mohamud R, A Garcia-Santana ML, Acevedo R, Sarmiento ME, Norazmi MN, Acosta A. Liposomes derived from Mycobacterium smegmatis promote immune activation of mice bone marrow-derived dendritic cells. Int J Mycobacteriol. 2020 Jul-Sep;9(3):261-267. doi: 10.4103/ijmy.ijmy_82_20. PMID: 32862158.