MedKoo Cat#: 574884 | Name: SX-011
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SX-011 is a p38α inhibitor that also inhibits p38β and JNK-2 but displays no significant activity at p38γ, p38δ, ERK-2 and JNK-1.

Chemical Structure

SX-011
SX-011
CAS#309913-42-6

Theoretical Analysis

MedKoo Cat#: 574884

Name: SX-011

CAS#: 309913-42-6

Chemical Formula: C26H27ClFN3O3

Exact Mass: 483.1725

Molecular Weight: 483.97

Elemental Analysis: C, 64.53; H, 5.62; Cl, 7.32; F, 3.93; N, 8.68; O, 9.92

Price and Availability

Size Price Availability Quantity
10mg USD 450.00 2 Weeks
50mg USD 1,200.00 2 Weeks
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Related CAS #
No Data
Synonym
SX-011; SX 011; SX011
IUPAC/Chemical Name
2-(6-chloro-5-(4-(4-fluorobenzyl)piperidine-1-carbonyl)-1-methyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide
InChi Key
GUTYHDCSDBBMGW-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H27ClFN3O3/c1-29(2)26(34)24(32)21-15-30(3)23-14-22(27)20(13-19(21)23)25(33)31-10-8-17(9-11-31)12-16-4-6-18(28)7-5-16/h4-7,13-15,17H,8-12H2,1-3H3
SMILES Code
O=C(C(N(C)C)=O)C2=CN(C)C1=CC(Cl)=C(C(N3CCC(CC4=CC=C(F)C=C4)CC3)=O)C=C12
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Solvent mg/mL mM
Solubility
DMSO 100.0 206.63
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 483.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Laufer, S., & Lehmann, F. (2009). Investigations of SCIO-469-like compounds for the inhibition of p38 MAP kinase. Bioorganic & Medicinal Chemistry Letters, 19(5), 1461-1464. Lee, M. R., & Dominguez, C. (2005). Map kinase p38inhibitors: Clinical results and an intimate look at their interactions with p38α protein. Current medicinal chemistry, 12(25), 2979-2994. MANI, SENDURAI A., STEVEN J. WERDEN, ANURAG N. PARANJAPE, RAMA SOUNDARARAJAN, NATALIA SPHYRIS, XIAOPING SUN, and SARADHI MALLAMPATI. "Sommaire du brevet 3010101."