ZD-6888 Hydrochloride | CAS#138620-17-4 | CAS#138620-04-9 | Angiotensin Type 1 Receptor Antagonist

MedKoo Cat#: 528421 | Name: ZD-6888 Hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ZD-6888 Hydrochloride, also known as ZD-6888 and ICI-D-6888, is an angiotensin type 1 receptor antagonist potentially for the treatment of hypertension.

Chemical Structure

ZD-6888 Hydrochloride

CAS#138620-17-4

Theoretical Analysis

MedKoo Cat#: 528421

Name: ZD-6888 Hydrochloride

CAS#: 138620-17-4

Chemical Formula: C25H26ClN5O

Exact Mass:

Molecular Weight: 447.97

Elemental Analysis: C, 67.03; H, 5.85; Cl, 7.91; N, 15.63; O, 3.57

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

138620-17-4 (HCl); 138620-04-9 (free)

Synonym

ZD-6888; ZD 6888; ZD6888; ZD-6888 HCl; ICI-D-6888; ICI D 6888; ICID6888

IUPAC/Chemical Name

4-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methoxy)-2-ethyl-5,6,7,8-tetrahydroquinoline hydrochloride

InChi Key

RPRNBLHRKYAXSM-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H25N5O.ClH/c1-2-19-15-24(22-9-5-6-10-23(22)26-19)31-16-17-11-13-18(14-12-17)20-7-3-4-8-21(20)25-27-29-30-28-25;/h3-4,7-8,11-15H,2,5-6,9-10,16H2,1H3,(H,27,28,29,30);1H

SMILES Code

CCC1=NC2=C(CCCC2)C(OCC3=CC=C(C4=CC=CC=C4C5=NNN=N5)C=C3)=C1.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 447.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Jackson DG, Jones HB. Histopathological and ultrastructural changes in the juxtaglomerular apparatus of the rat following administration of ZENECA ZD6888 (2-ethyl-5,6,7,8-tetrahydro-4-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)- methoxy]quinoline), an angiotensin II antagonist. Toxicol Pathol. 1995 Jan-Feb;23(1):7-15. PubMed PMID: 7770702. 2: Bradbury RH, Allott CP, Dennis M, Girdwood JA, Kenny PW, Major JS, Oldham AA, Ratcliffe AH, Rivett JE, Roberts DA, et al. New nonpeptide angiotensin II receptor antagonists. 3. Synthesis, biological properties, and structure-activity relationships of 2-alkyl-4-(biphenylylmethoxy)pyridine derivatives. J Med Chem. 1993 Apr 30;36(9):1245-54. PubMed PMID: 8487261.