RU-SKI 43 maleate | Hhat inhibitor

MedKoo Cat#: 574867 | Name: RU-SKI 43 maleate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RU-SKI 43 maleate is a potent and selective inhibitor of Hedgehog acyltransferase (Hhat).

Chemical Structure

RU-SKI 43 maleate

CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 574867

Name: RU-SKI 43 maleate

CAS#: Unknown

Chemical Formula: C52H68N4O12S2

Exact Mass: 1004.4275

Molecular Weight: 1005.25

Elemental Analysis: C, 62.13; H, 6.82; N, 5.57; O, 19.10; S, 6.38

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

1043797-53-0 (free base)

Synonym

RU-SKI 43 maleate

IUPAC/Chemical Name

1-[6,7-Dihydro-4-[(3-methylphenoxy)methyl]thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-ethanone maleate, 2-((2-Methylbutyl)amino)-1-(4-((m-tolyloxy)methyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone maleic acid salt

InChi Key

KUGIYWIFJKJYRD-FHQKDBNESA-N

InChi Code

InChI=1S/2C22H30N2O2S.2C4H4O4/c2*1-4-16(2)13-23-14-22(25)24-10-8-21-19(9-11-27-21)20(24)15-26-18-7-5-6-17(3)12-18;2*5-3(6)1-2-4(7)8/h2*5-7,9,11-12,16,20,23H,4,8,10,13-15H2,1-3H3;2*1-2H,(H,5,6)(H,7,8)/b;;2*2-1-

SMILES Code

CCC(C)CNCC(N1CCC2=C(C=CS2)C1COC3=CC=CC(C)=C3)=O.O=C(O)/C=C\C(O)=O.CC4=CC(OCC5C(C=CS6)=C6CCN5C(CNCC(C)CC)=O)=CC=C4.O=C(O)/C=C\C(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,005.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Petrova E, Matevossian A, Resh MD. Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene. 2015 Jan 8;34(2):263-8. doi: 10.1038/onc.2013.575. Epub 2014 Jan 27. PMID: 24469057; PMCID: PMC4513646. 2. Matevossian A, Resh MD. Hedgehog Acyltransferase as a target in estrogen receptor positive, HER2 amplified, and tamoxifen resistant breast cancer cells. Mol Cancer. 2015 Apr 1;14:72. doi: 10.1186/s12943-015-0345-x. PMID: 25889650; PMCID: PMC4711017.