SDM46326, also known as Rp-8-bromo-PET-Cyclic GMPS sodium salt is an analog of cyclic GMP (cGMP). It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP. In the absence of cGMP stimulation, Rp-8-bromo-PET-cGMPS can act as a partial agonist of cGKI. Rp-8-bromo-PET-cGMPS is resistant to hydrolysis by phosphodiesterase 11. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
MedKoo Cat#: 574862
Name: SDM46326
CAS#: 185246-32-6
Chemical Formula: C18H14BrN5NaO6PS
Exact Mass: 560.9483
Molecular Weight: 562.27
Elemental Analysis: C, 38.45; H, 2.51; Br, 14.21; N, 12.46; Na, 4.09; O, 17.07; P, 5.51; S, 5.70
The following data is based on the product molecular weight 562.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
