NSC-45586 | CAS# 6300-44-3 | pan-PHLPP inhibitor

MedKoo Cat#: 574823 | Name: NSC-45586

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NSC-45586 is a pan-PHLPP inhibitor selective for PHLPP1 and PHLPP2.

Chemical Structure

NSC-45586

CAS#6300-44-3

Theoretical Analysis

MedKoo Cat#: 574823

Name: NSC-45586

CAS#: 6300-44-3

Chemical Formula: C20H17N6NaO3

Exact Mass: 0.0000

Molecular Weight: 412.38

Elemental Analysis: C, 58.25; H, 4.16; N, 20.38; Na, 5.57; O, 11.64

Price and Availability

Size	Price	Availability
50mg	USD 450.00	2 Weeks
100mg	USD 750.00	2 Weeks
200mg	USD 1,250.00	2 Weeks
500mg	USD 2,150.00	2 Weeks
1g	USD 2,950.00	2 Weeks
2g	USD 5,150.00	2 Weeks

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Related CAS #

No Data

Synonym

NSC-45586; NSC45586; NSC 45586

IUPAC/Chemical Name

Sodium 3-[[4-[(2,4-diamino-5-methylphenyl)diazenyl]phenyl]hydrazinylidene]-6-oxocyclohexa-1,4-diene-1-carboxylate

InChi Key

IVOYTGYCZAPITD-MGVQZJJESA-M

InChi Code

InChI=1S/C20H18N6O3.Na/c1-11-8-18(17(22)10-16(11)21)26-24-13-4-2-12(3-5-13)23-25-14-6-7-19(27)15(9-14)20(28)29;/h2-10,23H,21-22H2,1H3,(H,28,29);/q;+1/p-1/b25-14+,26-24+;

SMILES Code

O=C(C1=C/C(C=CC1=O)=N/NC2=CC=C(/N=N/C3=CC(C)=C(N)C=C3N)C=C2)[O-].[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

NSC45586 sodium is an inhibitor of pleckstrin homology domain and leucine-rich repeat protein phosphatase (PHLPP).

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMSO	82.0	198.84

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 412.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1. Jackson TC, Verrier JD, Drabek T, Janesko-Feldman K, Gillespie DG, Uray T, Dezfulian C, Clark RS, Bayir H, Jackson EK, Kochanek PM. Pharmacological inhibition of pleckstrin homology domain leucine-rich repeat protein phosphatase is neuroprotective: differential effects on astrocytes. J Pharmacol Exp Ther. 2013 Nov;347(2):516-28. doi: 10.1124/jpet.113.206888. Epub 2013 Sep 10. PMID: 24023368; PMCID: PMC3807060.