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MedKoo Cat#: 463020 | Name: Amoorastatin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Amoorastatin is a natural product that has been studied in cancer research. Its derivative was found to significantly inhibit growth of the murine P388 lymphocytic leukemia cell lines.

Chemical Structure

Amoorastatin
Amoorastatin
CAS#68985-96-6

Theoretical Analysis

MedKoo Cat#: 463020

Name: Amoorastatin

CAS#: 68985-96-6

Chemical Formula: C28H36O9

Exact Mass: 516.2359

Molecular Weight: 516.59

Elemental Analysis: C, 65.10; H, 7.02; O, 27.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
28R-Amoorastatin; 28RAmoorastatin; 28R Amoorastatin;
IUPAC/Chemical Name
(1S,2aR,3aR,3bS,4R,5aR,7R,9S,9aS,9bR,11aS)-1-(furan-3-yl)-4,9,14-trihydroxy-3b,6,11a-trimethyl-10-oxotetradecahydro-1H-6,9a-(methanooxymethano)naphtho[1',2':6,7]indeno[1,7a-b]oxiren-7-yl acetate
InChi Key
DTKVYFQSFHHKAR-WQRSBWJWSA-N
InChi Code
InChI=1S/C28H36O9/c1-13(29)36-20-9-19(32)27-12-35-23(33)25(20,3)17(27)8-18(31)26(4)22(27)16(30)10-24(2)15(14-5-6-34-11-14)7-21-28(24,26)37-21/h5-6,11,15,17-23,31-33H,7-10,12H2,1-4H3/t15-,17-,18+,19-,20+,21+,22-,23?,24-,25?,26+,27+,28+/m0/s1
SMILES Code
CC(O[C@@H]1C[C@@H]([C@@]23COC(C1([C@@H]2C[C@H]([C@@]4([C@@H]3C(C[C@]5([C@H](c6ccoc6)C[C@H]7O[C@@]457)C)=O)C)O)C)O)O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 516.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nerome K, Ito-Kureha T, Paganini T, Fukuda T, Igarashi Y, Ashitomi H, Ikematsu S, Yamamoto T. Potent and broad anticancer activities of leaf extracts from Melia azedarach L. of the subtropical Okinawa islands. Am J Cancer Res. 2020 Feb 1;10(2):581-594. PMID: 32195029; PMCID: PMC7061759. 2: Vardamides JC, Dongo E, Nkengfack AE, Fomum ZT, Ngando TM, Vogler B, Kraus W. Diterpenoid and limonoids from the stem of Pterorhachis zenkeri. Fitoterapia. 2001 May;72(4):386-93. doi: 10.1016/s0367-326x(00)00341-5. PMID: 11395261. 3: Polonsky J, Varon Z, Marazano C, Arnoux B, Pettit GR, Schmid JM, Ochi M, Kotsuki H. The structure of amoorastatone and the cytotoxic limonoid 12-hydroxyamoorastatin. Experientia. 1979 Aug 15;35(8):987-9. doi: 10.1007/BF01949897. PMID: 477905.