Synonym
AP1510; AP 1510; AP-1510
IUPAC/Chemical Name
(1R,1'R)-((((ethane-1,2-diylbis(azanediyl))bis(2-oxoethane-2,1-diyl))bis(oxy))bis(3,1-phenylene))bis(3-(3,4-dimethoxyphenyl)propane-1,1-diyl) (2S,2'S)-bis(1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate)
InChi Key
AVCOECAXJAPZMZ-AJLWXHIPSA-N
InChi Code
InChI=1S/C66H86N4O16/c1-11-65(3,4)59(73)61(75)69-35-15-13-23-49(69)63(77)85-51(29-25-43-27-31-53(79-7)55(37-43)81-9)45-19-17-21-47(39-45)83-41-57(71)67-33-34-68-58(72)42-84-48-22-18-20-46(40-48)52(30-26-44-28-32-54(80-8)56(38-44)82-10)86-64(78)50-24-14-16-36-70(50)62(76)60(74)66(5,6)12-2/h17-22,27-28,31-32,37-40,49-52H,11-16,23-26,29-30,33-36,41-42H2,1-10H3,(H,67,71)(H,68,72)/t49-,50-,51+,52+/m0/s1
SMILES Code
CC(C)(CC)C(C(N(CCCC1)[C@@H]1C(O[C@H](CCC2=CC=C(C(OC)=C2)OC)C3=CC=CC(OCC(NCCNC(COC4=CC([C@H](OC([C@@H]5CCCCN5C(C(C(C)(C)CC)=O)=O)=O)CCC6=CC=C(OC)C(OC)=C6)=CC=C4)=O)=O)=C3)=O)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
1,191.43
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Ramesh M, Krishnan N, Muthuswamy SK, Tonks NK. A novel phosphatidic acid-protein-tyrosine phosphatase D2 axis is essential for ERBB2 signaling in mammary epithelial cells. J Biol Chem. 2015 Apr 10;290(15):9646-59. doi: 10.1074/jbc.M114.627968. Epub 2015 Feb 13. PubMed PMID: 25681440; PubMed Central PMCID: PMC4392266.
2: Ghosh R, Narasanna A, Wang SE, Liu S, Chakrabarty A, Balko JM, González-Angulo AM, Mills GB, Penuel E, Winslow J, Sperinde J, Dua R, Pidaparthi S, Mukherjee A, Leitzel K, Kostler WJ, Lipton A, Bates M, Arteaga CL. Trastuzumab has preferential activity against breast cancers driven by HER2 homodimers. Cancer Res. 2011 Mar 1;71(5):1871-82. doi: 10.1158/0008-5472.CAN-10-1872. Epub 2011 Feb 15. PubMed PMID: 21324925; PubMed Central PMCID: PMC3221734.
3: Lucas PC, Kuffa P, Gu S, Kohrt D, Kim DS, Siu K, Jin X, Swenson J, McAllister-Lucas LM. A dual role for the API2 moiety in API2-MALT1-dependent NF-kappaB activation: heterotypic oligomerization and TRAF2 recruitment. Oncogene. 2007 Aug 16;26(38):5643-54. Epub 2007 Mar 5. PubMed PMID: 17334391.
4: Kley N. Chemical dimerizers and three-hybrid systems: scanning the proteome for targets of organic small molecules. Chem Biol. 2004 May;11(5):599-608. Review. PubMed PMID: 15157871.
5: Yang W, Keenan TP, Rozamus LW, Wang X, Rivera VM, Rollins CT, Clackson T, Holt DA. Regulation of gene expression by synthetic dimerizers with novel specificity. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3181-4. PubMed PMID: 12951089.
