Synonym
Etintidine hydrochloride
IUPAC/Chemical Name
Guanidine, N''-cyano-N-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)-N'-2-propynyl-, monohydrochloride
InChi Key
BHEZOMBVJJYAFT-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H16N6S.ClH/c1-3-4-14-12(16-8-13)15-5-6-19-7-11-10(2)17-9-18-11;/h1,9H,4-7H2,2H3,(H,17,18)(H2,14,15,16);1H
SMILES Code
C#CCN/C(NCCSCC1=C(C)NC=N1)=N\C#N.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
312.82
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Cavanagh RL, Usakewicz JJ, Buyniski JP. A comparison of some of the pharmacological properties of etintidine, a new histamine H2-receptor antagonist, with those of cimetidine, ranitidine and tiotidine. J Pharmacol Exp Ther. 1983 Jan;224(1):171-9. PMID: 6129316.
2: Huang SM, Marriott TB, Weintraub HS, Boccagno JA, Abels R. The effect of food or milk on the bioavailability of etintidine in healthy subjects. Int J Clin Pharmacol Ther Toxicol. 1988 Mar;26(3):113-7. PMID: 2900817.
3: Huang SM, Rubin E, Marriott TB. A high-performance liquid chromatographic microassay employing a liquid-solid extraction technique for etintidine in plasma. Pharm Res. 1987 Apr;4(2):133-6. doi: 10.1023/a:1016419019715. PMID: 3509136.
4: Schulz M, Schmoldt A. Interactions of the histamine H2-receptor antagonist etintidine with rat liver cytochrome P-450: a comparison with cimetidine. Naunyn Schmiedebergs Arch Pharmacol. 1987 Oct;336(4):453-8. doi: 10.1007/BF00164882. PMID: 2893298.
5: Müller P, Dammann HG, Simon B. Einmal abendliche Gabe von Etintidin beim Menschen: Wirkung auf Süresekretion und Verhalten wichtiger Hormone [Single evening administration of etintidine in the human: effect on acid secretion and behavior of important hormones]. Z Gastroenterol. 1985 Mar;23(3):115-20. German. PMID: 2867653.
6: Huang SM, Weintraub HS, Marriott TB, Marinan B, Abels R. Etintidine- propranolol interaction study in humans. J Pharmacokinet Biopharm. 1987 Dec;15(6):557-68. doi: 10.1007/BF01068412. PMID: 2897462.
7: Huang SM, Weintraub HS, Marriott TB, Marinan B, Abels R, Leese PT. Etintidine-theophylline interaction study in humans. Biopharm Drug Dispos. 1987 Nov-Dec;8(6):561-9. doi: 10.1002/bdd.2510080607. PMID: 2892545.
8: Dammann HG, Rehner M, Dreyer M, Walter TA, Müller P, Simon B. Wirkung verschiedener Dosierungen des neuen Imidazol-H2-Rezeptorantagonisten Etintidin auf die intragastrale Azidität des Menschen [The action of various doses of the new imidazole H2-receptor antagonist etintidine on intragastric acidity in man]. Arzneimittelforschung. 1986 Nov;36(11):1699-701. German. PMID: 2880596.
9: Scott CK, Katz LB, Shriver DA. Pharmacological profile of etintidine, a new histamine H2-receptor antagonist. Arch Int Pharmacodyn Ther. 1986 May;281(1):5-21. PMID: 2875695.
10: Huang SM, Marriott TB, Weintraub HS, Arnold JD, Boccagno J, Abels R, Harris W. Single-dose and multiple-dose pharmacokinetics of etintidine in healthy volunteers. Eur J Clin Pharmacol. 1988;34(1):101-4. doi: 10.1007/BF01061428. PMID: 2896125.
