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MedKoo Cat#: 408121 | Name: SR-717 free acid

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SR-717 is an agonist of stimulator of interferon genes STING for treating cancer. SR-717 demonstrates broad interspecies and interallelic specificity. SR-717 functions as a direct cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic that induces the same "closed" conformation of STING. SR-717 displayed antitumor activity; promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitated antigen cross-priming. SR-717 also induced the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner.

Chemical Structure

SR-717 free acid
CAS#2375420-34-9 (free acid)

Theoretical Analysis

MedKoo Cat#: 408121

Name: SR-717 free acid

CAS#: 2375420-34-9 (free acid)

Chemical Formula: C15H9F2N5O3

Exact Mass: 345.0673

Molecular Weight: 345.27

Elemental Analysis: C, 52.18; H, 2.63; F, 11.01; N, 20.28; O, 13.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
2375420-34-9 (free acid) 2375421-09-1 (lithium)
Synonym
SR-717 free acid; SR 717; SR717;
IUPAC/Chemical Name
2-(6-(1H-imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoic acid
InChi Key
WEBVQIJGIZVRGA-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H9F2N5O3/c16-9-5-8(15(24)25)12(6-10(9)17)19-14(23)11-1-2-13(21-20-11)22-4-3-18-7-22/h1-7H,(H,19,23)(H,24,25)
SMILES Code
O=C(C1=CC(F)=C(C=C1NC(C2=NN=C(C=C2)N3C=CN=C3)=O)F)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Stimulator of interferon genes (STING) links innate immunity to biological processes ranging from antitumor immunity to microbiome homeostasis. Mechanistic understanding of the anticancer potential for STING receptor activation is currently limited by metabolic instability of the natural cyclic dinucleotide (CDN) ligands.

Preparing Stock Solutions

The following data is based on the product molecular weight 345.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chin EN, Yu C, Vartabedian VF, Jia Y, Kumar M, Gamo AM, Vernier W, Ali SH, Kissai M, Lazar DC, Nguyen N, Pereira LE, Benish B, Woods AK, Joseph SB, Chu A, Johnson KA, Sander PN, Martínez-Peña F, Hampton EN, Young TS, Wolan DW, Chatterjee AK, Schultz PG, Petrassi HM, Teijaro JR, Lairson LL. Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic. Science. 2020 Aug 21;369(6506):993-999. doi: 10.1126/science.abb4255. PMID: 32820126. 2: Caldwell SE, Janosko CP, Deiters A. Development of a light-activated STING agonist. Org Biomol Chem. 2024 Jan 3;22(2):302-308. doi: 10.1039/d3ob01578e. PMID: 38054844. 3: Wang H, Liu Z, Fang Y, Luo X, Zheng C, Xu Y, Zhou X, Yuan Q, Lv S, Ma L, Lao YH, Tao Y, Li M. Spatiotemporal release of non-nucleotide STING agonist and AKT inhibitor from implantable 3D-printed scaffold for amplified cancer immunotherapy. Biomaterials. 2024 Dec;311:122645. doi: 10.1016/j.biomaterials.2024.122645. Epub 2024 May 28. PMID: 38850717. 4: Li H, Zhang C, Chen Y, Xu Y, Yao W, Fan W. Biodegradable Long-Circulating Nanoagonists Optimize Tumor-Tropism Chemo-Metalloimmunotherapy for Boosted Antitumor Immunity by Cascade cGAS-STING Pathway Activation. ACS Nano. 2024 Aug 27;18(34):23711-23726. doi: 10.1021/acsnano.4c08463. Epub 2024 Aug 16. PMID: 39148423. 5: Zhou XW, Wang J, Tan WF. Apigenin Suppresses Innate Immune Responses and Ameliorates Lipopolysaccharide-Induced Inflammation via Inhibition of STING/IRF3 Pathway. Am J Chin Med. 2024;52(2):471-492. doi: 10.1142/S0192415X24500204. Epub 2024 Mar 14. PMID: 38480499. 6: Zou SS, Qiao Y, Zhu S, Gao B, Yang N, Liu YJ, Chen J. Intrinsic strategies for the evasion of cGAS-STING signaling-mediated immune surveillance in human cancer: How therapy can overcome them. Pharmacol Res. 2021 Apr;166:105514. doi: 10.1016/j.phrs.2021.105514. Epub 2021 Feb 23. PMID: 33631336. 7: Huang R, Shi Q, Zhang S, Lin H, Han C, Qian X, Huang Y, Ren X, Sun J, Feng N, Xia C, Shi M. Inhibition of the cGAS-STING Pathway Attenuates Lung Ischemia/Reperfusion Injury via Regulating Endoplasmic Reticulum Stress in Alveolar Epithelial Type II Cells of Rats. J Inflamm Res. 2022 Sep 5;15:5103-5119. doi: 10.2147/JIR.S365970. PMID: 36091334; PMCID: PMC9462969. 8: Lin C, He C, Li L, Liu Y, Tang L, Ni Z, Zhang N, Lai T, Chen X, Wang X. Alpha-lipoic acid (ALA) ameliorates early brain injury after subarachnoid hemorrhage in Sprague-Dawley (SD) rats via inhibiting STING-NLRP3 inflammatory signaling. Neuroreport. 2024 Mar 6;35(4):250-257. doi: 10.1097/WNR.0000000000001998. Epub 2024 Jan 15. PMID: 38305103; PMCID: PMC10852041. 9: Gao Y, Ling Y, Wu H, Zhang P, Zhou J, Gu H, Yang J, Zhou Y, Zhong Z, Chi J. Swimming training attenuates doxorubicin induced cardiomyopathy by targeting the mir-17-3p/KEAP1/NRF2 axis. Biochem Biophys Res Commun. 2024 Dec 20;739:150568. doi: 10.1016/j.bbrc.2024.150568. Epub 2024 Aug 19. PMID: 39178797. 10: Bi R, Yang Y, Liao H, Ji G, Ma Y, Cai L, Li J, Yang J, Sun M, Liang J, Shi L. Porphyromonas gingivalis induces an inflammatory response via the cGAS-STING signaling pathway in a periodontitis mouse model. Front Microbiol. 2023 Jun 19;14:1183415. doi: 10.3389/fmicb.2023.1183415. PMID: 37405166; PMCID: PMC10315844.