BPN-14136 is a novel Retinol-Binding Protein 4 (RBP4) antagonist that reduces serum retinol concentrations, thereby decreasing retinal bisretinoid synthesis linked to macular degeneration. In cynomolgus monkeys, oral administration of BPN-14136 resulted in a 99% reduction of serum RBP4, demonstrating strong bioactivity. Pharmacokinetic studies showed high compound exposure in non-human primates (NHP) with favorable pharmacokinetics and pharmacodynamics. The study recommended NHP as the preferred non-rodent species for safety evaluation due to similarities in retinoid trafficking with humans
MedKoo Cat#: 462965
Name: BPN-14136
CAS#: 1628945-93-6
Chemical Formula: C20H20F3N3O2
Exact Mass: 391.1508
Molecular Weight: 391.39
Elemental Analysis: C, 61.38; H, 5.15; F, 14.56; N, 10.74; O, 8.18
The following data is based on the product molecular weight 391.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
