Synonym
ML-261; ML 261; ML261; CID-9550710; CID9550710; CID 9550710
IUPAC/Chemical Name
2-chloro-N-[2-(3,4-diethoxyphenyl)ethyl]-4-methyl-4H-thieno[3,2-b]pyrrole-5-carboxamide
InChi Key
DGNXYXASQJMULD-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H23ClN2O3S/c1-4-25-16-7-6-13(10-17(16)26-5-2)8-9-22-20(24)15-11-18-14(23(15)3)12-19(21)27-18/h6-7,10-12H,4-5,8-9H2,1-3H3,(H,22,24)
SMILES Code
CCOC1=C(OCC)C=C(CCNC(C2=CC(SC(Cl)=C3)=C3N2C)=O)C=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
ML261 is a hepatic lipid droplets formation inhibitor with an IC50 value of 69.7 nM.
|
Solvent |
mg/mL |
mM |
| Solubility |
| DMSO |
5.0 |
12.29 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
406.93
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
TBD
Zou J, Ganji S, Pass I, Ardecky R, Peddibhotla M, Loribelle M, Heynen-Genel S, Sauer M, Pass I, Vasile S, Suyama E, Malany S, Mangravita-Novo A, Vicchiarelli M, McAnally D, Cheltsov A, Derek S, Shi S, Su Y, Zeng FY, Pinkerton AB, Smith LH, Kim S, Ngyuen H, Zeng FY, Diwan J, Heisel AJ, Coleman R, McDonough PM, Chung TDY. Potent inhibitors of lipid droplet formation. 2011 Oct 31 [updated 2014 May 13]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 23762932.
