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MedKoo Cat#: 207147 | Name: CFT-743

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CFT-743 is a potent BET degrader. In vitro, CFT-743 is more potent than a BET inhibitor (AZD5153) and a CDK9 inhibitor (dinaciclib) in 100% and 97% of 38 leukemia lines tested. In mice bearing HL60 tumors, CFT-743 has similar efficacy as dinaciclib (81% regression versus 99% tumor growth inhibition (TGI)).

Chemical Structure

CFT-743
CFT-743
CAS#2154350-81-7

Theoretical Analysis

MedKoo Cat#: 207147

Name: CFT-743

CAS#: 2154350-81-7

Chemical Formula: C46H49ClN10O3

Exact Mass: 824.3678

Molecular Weight: 825.42

Elemental Analysis: C, 66.94; H, 5.98; Cl, 4.29; N, 16.97; O, 5.81

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CFT-743; CFT 743; CFT743;
IUPAC/Chemical Name
3-(4-((1-(6-(4-(6-(4-chlorophenyl)-1-methylspiro[benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine-4,1'-cyclopropan]-8-yl)-1H-pyrazol-1-yl)hexyl)piperidin-4-yl)amino)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
InChi Key
LPEKKFOJGTZRLY-UHFFFAOYSA-N
InChi Code
InChI=1S/C46H49ClN10O3/c1-29-52-53-45-46(19-20-46)51-42(30-9-12-33(47)13-10-30)36-25-31(11-14-39(36)57(29)45)32-26-48-55(27-32)22-5-3-2-4-21-54-23-17-34(18-24-54)49-38-8-6-7-35-37(38)28-56(44(35)60)40-15-16-41(58)50-43(40)59/h6-14,25-27,34,40,49H,2-5,15-24,28H2,1H3,(H,50,58,59)
SMILES Code
O=C1N(CC2=C(C=CC=C21)NC3CCN(CC3)CCCCCCN4N=CC(C5=CC6=C(C=C5)N7C(C)=NN=C7C8(CC8)N=C6C9=CC=C(C=C9)Cl)=C4)C%10C(NC(CC%10)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Targeted protein degradation (TPD) with heterobifunctional small molecules is emerging as a promising new therapeutic modality in oncology. We sought to understand how TPD compares versus targeted protein inhibition.

Preparing Stock Solutions

The following data is based on the product molecular weight 825.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL