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MedKoo Cat#: 574794 | Name: ML-148
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ML-148, also known as CID-3243760, is an inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH).

Chemical Structure

ML-148
ML-148
CAS#451496-96-1

Theoretical Analysis

MedKoo Cat#: 574794

Name: ML-148

CAS#: 451496-96-1

Chemical Formula: C20H21N3O

Exact Mass: 319.1685

Molecular Weight: 319.41

Elemental Analysis: C, 75.21; H, 6.63; N, 13.16; O, 5.01

Price and Availability

Size Price Availability Quantity
25mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
100mg USD 1,250.00 2 Weeks
200mg USD 2,150.00 2 Weeks
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Related CAS #
No Data
Synonym
ML-148; ML148; ML148; CID-3243760; CID3243760; CID 3243760;
IUPAC/Chemical Name
[1-(3-methylphenyl)-1H-benzimidazol-5-yl]-1-piperidinyl-methanone
InChi Key
YQNOQZALLOQMPY-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H21N3O/c1-15-6-5-7-17(12-15)23-14-21-18-13-16(8-9-19(18)23)20(24)22-10-3-2-4-11-22/h5-9,12-14H,2-4,10-11H2,1H3
SMILES Code
O=C(C1=CC=C2C(N=CN2C3=CC=CC(C)=C3)=C1)N4CCCCC4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
ML148 is a potent and selective 15-PGDH inhibitor with an IC50 of 56 nM.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM comments
Solubility
DMF 25.0 78.27
DMF:PBS (pH 7.2) (1:1) 0.5 1.57
DMSO 27.5 86.10
Ethanol 10.0 31.31
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 319.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1. Niesen, F.H., Schultz, L., Jadhav, A., et al. High-affinity inhibitors of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase: Mechanisms of inhibition and structure-activity relationships. PLoS One 5(11), 1-12 (2010).