MedKoo Cat#: 574763 | Name: K-579
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

K-579 is a Dipeptidyl peptidase IV inhibitor and long-acting hypoglycemic agent that attenuates glucose excursion following glucose loading.

Chemical Structure

K-579
K-579
CAS# 440100-64-1

Theoretical Analysis

MedKoo Cat#: 574763

Name: K-579

CAS#: 440100-64-1

Chemical Formula: C17H24N6O

Exact Mass: 328.2012

Molecular Weight: 328.42

Elemental Analysis: C, 62.17; H, 7.37; N, 25.59; O, 4.87

Price and Availability

Size Price Availability Quantity
10mg USD 550.00 2 Weeks
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Related CAS #
No Data
Synonym
K 579; K579; K-579
IUPAC/Chemical Name
(2S)-1-[[[4-Methyl-1-(2-pyrimidinyl)-4-piperidinyl]amino]acetyl]-2-pyrrolidinecarbonitrile
InChi Key
JERPHRNGJBSFAP-AWEZNQCLSA-N
InChi Code
InChI=1S/C17H24N6O/c1-17(21-13-15(24)23-9-2-4-14(23)12-18)5-10-22(11-6-17)16-19-7-3-8-20-16/h3,7-8,14,21H,2,4-6,9-11,13H2,1H3/t14-/m0/s1
SMILES Code
N#C[C@H]1N(C(CNC2(C)CCN(C3=NC=CC=N3)CC2)=O)CCC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 328.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Takasaki et al (2004) K579, a slow-binding inhibitor of dipeptidyl peptidase IV, is a long-acting hypoglycemic agent. Eur.J.Pharmacol. 486 335 PMID: 14985056 2. Takasaki et al (2004) Effects of combination treatment with dipeptidyl peptidase IV inhibitor and sulfonylurea on glucose levels in rats. J.Pharmacol.Sci. 95 291 PMID: 15215655 3. Takasaki et al (2004) Involvement of the active metabolites in the inhibitory activity of K579 on rat plasma dipeptidyl peptidase IV. Eur.J.Pharmacol. 505 237 PMID: 15556158