R1498 | CAS#303196-31-8 | CDK2 inhibitor

MedKoo Cat#: 563055 | Name: R1498

Description:

WARNING: This product is for research use only, not for human or veterinary use.

R1498 is an inhibitor of cyclin-dependent kinase 2 (CDK2). It is well-tolerated and orally active for hepatocellular carcinoma and gastric cancer treatment and acts via targeting angiogenesis and mitosis pathways.

Chemical Structure

R1498

CAS#303196-31-8

Theoretical Analysis

MedKoo Cat#: 563055

Name: R1498

CAS#: 303196-31-8

Chemical Formula: C18H15ClN4O

Exact Mass: 338.0934

Molecular Weight: 338.79

Elemental Analysis: C, 63.81; H, 4.46; Cl, 10.46; N, 16.54; O, 4.72

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

R1498; R-1498; R 1498;

IUPAC/Chemical Name

5-(2-Chlorophenyl)-1,2-dihydro-7-methoxy-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine

InChi Key

DPNXJZDCWBJDSX-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H15ClN4O/c1-10-16-18(23-22-10)20-15-8-7-11(24-2)9-13(15)17(21-16)12-5-3-4-6-14(12)19/h3-9H,1-2H3,(H2,20,22,23)

SMILES Code

CC(NN1)=C2C1=NC3=CC=C(OC)C=C3C(C4=CC=CC=C4Cl)=N2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 338.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Thunhorst RL, Beltz TG, Johnson AK. Effects of aging on mineralocorticoid-induced salt appetite in rats. Am J Physiol Regul Integr Comp Physiol. 2013 Dec 15;305(12):R1498-505. doi: 10.1152/ajpregu.00349.2013. Epub 2013 Oct 16. PubMed PMID: 24133100; PubMed Central PMCID: PMC3882696. 2: Zhang C, Wu X, Zhang M, Zhu L, Zhao R, Xu D, Lin Z, Liang C, Chen T, Chen L, Ren Y, Zhang J, Qin N, Zhang X. Small molecule R1498 as a well-tolerated and orally active kinase inhibitor for hepatocellular carcinoma and gastric cancer treatment via targeting angiogenesis and mitosis pathways. PLoS One. 2013 Jun 5;8(6):e65264. doi: 10.1371/journal.pone.0065264. Print 2013. PubMed PMID: 23755206; PubMed Central PMCID: PMC3673949. 3: Ray R, Herring CM, Markel TA, Crisostomo PR, Wang M, Weil B, Lahm T, Meldrum DR. Deleterious effects of endogenous and exogenous testosterone on mesenchymal stem cell VEGF production. Am J Physiol Regul Integr Comp Physiol. 2008 May;294(5):R1498-503. doi: 10.1152/ajpregu.00897.2007. Epub 2008 Mar 12. PubMed PMID: 18337309.