Ibufenac is a propionic acid-class nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, providing analgesic, antipyretic, and anti-inflammatory effects. It was withdrawn from the market due to hepatotoxicity, attributed to reactive acyl-glucuronide metabolites that cause liver cell damage. Ibufenac’s safety concerns led to the development of safer alternatives like ibuprofen, which retains similar therapeutic effects with a better toxicity profile.
MedKoo Cat#: 574741
Name: Ibufenac
CAS#: 1553-60-2
Chemical Formula: C12H16O2
Exact Mass: 192.1150
Molecular Weight: 192.26
Elemental Analysis: C, 74.97; H, 8.39; O, 16.64
The following data is based on the product molecular weight 192.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
