Ibandronic Acid | CAS# 114084-78-5 | Bone resorption inhibitor

MedKoo Cat#: 574740 | Name: Ibandronic Acid

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ibandronic Acid is a bisphosphonate anti-resorptive agent and bone resorption inhibitor.

Chemical Structure

Ibandronic Acid

CAS#114084-78-5

Theoretical Analysis

MedKoo Cat#: 574740

Name: Ibandronic Acid

CAS#: 114084-78-5

Chemical Formula: C9H23NO7P2

Exact Mass: 319.0950

Molecular Weight: 319.23

Elemental Analysis: C, 33.86; H, 7.26; N, 4.39; O, 35.08; P, 19.41

Price and Availability

Size	Price	Availability
1g	USD 250.00	2 Weeks
5g	USD 650.00	2 Weeks
10g	USD 950.00	2 Weeks

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Synonym

Ibandronic Acid; BPH 24; Ibandronate

IUPAC/Chemical Name

P,P'-[1-Hydroxy-3-(methylpentylamino)propylidene]bisphosphonic Acid

InChi Key

MPBVHIBUJCELCL-UHFFFAOYSA-N

InChi Code

InChI=1S/C9H23NO7P2/c1-3-4-5-7-10(2)8-6-9(11,18(12,13)14)19(15,16)17/h11H,3-8H2,1-2H3,(H2,12,13,14)(H2,15,16,17)

SMILES Code

CCCCCN(CCC(P(O)(O)=O)(P(O)(O)=O)O)C

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

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Product Data

Product Data

Instruction

View handling instruction

Biological target:

Ibandronic acid is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.

In vitro activity:

In lines with western blot, the results of autophagy flux and TEM assay further confirmed that autophagy, occurred in Ang II + IBAN group, was higher than that in the untreated and Ang II or IBAN-treated groups (Fig. 2B, C). Therefore, these findings demonstrated that IBAN promoted autophagy in Ang II-treated HUVECs and human pulmonary microvascular endothelial cells (HPMECs). Reference: Cell Death Discov. 2022 Apr 9;8(1):186. https://pubmed.ncbi.nlm.nih.gov/35397636/

In vivo activity:

Administration of IBN (ibandronate) at 1 μg/kg (IBN_1) was insufficient for the suppression of bone loss and morphological change in trabeculae; however, administration of 3 μg/kg (IBN_3) and 10 μg/kg (IBN_10) significantly suppressed the osteoporotic changes induced by estrogen deficiency. Reference: Calcif Tissue Int. 2022 Jun;110(6):736-745. https://pubmed.ncbi.nlm.nih.gov/34989822/

Preparing Stock Solutions

The following data is based on the product molecular weight 319.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Han J, Yang J, Wang Q, Yin X, Sun Z, Huang C, Chen G, Zheng L, Jiang D. Ibandronate promotes autophagy by inhibiting Rac1-mTOR signaling pathway in vitro and in vivo. Cell Death Discov. 2022 Apr 9;8(1):186. doi: 10.1038/s41420-022-00995-6. PMID: 35397636; PMCID: PMC8994753. 2. Lotz EM, Cohen DJ, Ellis RA, Wayne JS, Schwartz Z, Boyan BD. Ibandronate Treatment Before and After Implant Insertion Impairs Osseointegration in Aged Rats with Ovariectomy Induced Osteoporosis. JBMR Plus. 2019 Mar 6;3(7):e10184. doi: 10.1002/jbm4.10184. PMID: 31372590; PMCID: PMC6659452. 3. Ishimoto T, Saito M, Ozasa R, Matsumoto Y, Nakano T. Ibandronate Suppresses Changes in Apatite Orientation and Young's Modulus Caused by Estrogen Deficiency in Rat Vertebrae. Calcif Tissue Int. 2022 Jun;110(6):736-745. doi: 10.1007/s00223-021-00940-2. Epub 2022 Jan 6. PMID: 34989822; PMCID: PMC9108105. 4. Takeda S, Sakai S, Tanaka K, Tomizawa H, Serizawa K, Yogo K, Urayama K, Hashimoto J, Endo K, Matsumoto Y. Intermittent Ibandronate Maintains Bone Mass, Bone Structure, and Biomechanical Strength of Trabecular and Cortical Bone After Discontinuation of Parathyroid Hormone Treatment in Ovariectomized Rats. Calcif Tissue Int. 2017 Jul;101(1):65-74. doi: 10.1007/s00223-017-0255-6. Epub 2017 Feb 28. PMID: 28246925; PMCID: PMC5486915.

In vitro protocol:

In vivo protocol:

1. Ishimoto T, Saito M, Ozasa R, Matsumoto Y, Nakano T. Ibandronate Suppresses Changes in Apatite Orientation and Young's Modulus Caused by Estrogen Deficiency in Rat Vertebrae. Calcif Tissue Int. 2022 Jun;110(6):736-745. doi: 10.1007/s00223-021-00940-2. Epub 2022 Jan 6. PMID: 34989822; PMCID: PMC9108105. 2. Takeda S, Sakai S, Tanaka K, Tomizawa H, Serizawa K, Yogo K, Urayama K, Hashimoto J, Endo K, Matsumoto Y. Intermittent Ibandronate Maintains Bone Mass, Bone Structure, and Biomechanical Strength of Trabecular and Cortical Bone After Discontinuation of Parathyroid Hormone Treatment in Ovariectomized Rats. Calcif Tissue Int. 2017 Jul;101(1):65-74. doi: 10.1007/s00223-017-0255-6. Epub 2017 Feb 28. PMID: 28246925; PMCID: PMC5486915.

1. McCormack PL, Plosker GL. Ibandronic acid: a review of its use in the treatment of bone metastases of breast cancer. Drugs. 2006;66(5):711-728. doi:10.2165/00003495-200666050-00011 2. Barrett-Lee P, Casbard A, Abraham J, et al. Oral ibandronic acid versus intravenous zoledronic acid in treatment of bone metastases from breast cancer: a randomised, open label, non-inferiority phase 3 trial [published correction appears in Lancet Oncol. 2014 Feb;15(2):e52-3]. Lancet Oncol. 2014;15(1):114-122. doi:10.1016/S1470-2045(13)70539-4