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MedKoo Cat#: 574728 | Name: Hemustine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hemustine is an inhibitor of human glutathione reductase and widely used as an anti-tumor agent.

Chemical Structure

Hemustine
Hemustine
CAS#60784-46-5

Theoretical Analysis

MedKoo Cat#: 574728

Name: Hemustine

CAS#: 60784-46-5

Chemical Formula: C5H10ClN3O3

Exact Mass: 195.0411

Molecular Weight: 195.60

Elemental Analysis: C, 30.70; H, 5.15; Cl, 18.12; N, 21.48; O, 24.54

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Related CAS #
No Data
Synonym
Hemustine; Elmustine; HECNU; NSC 294895
IUPAC/Chemical Name
N-(2-Chloroethyl)-N'-(2-hydroxyethyl)-N-nitrosourea
InChi Key
YJZJEQBSODVMTH-UHFFFAOYSA-N
InChi Code
InChI=1S/C5H10ClN3O3/c6-1-3-9(8-12)5(11)7-2-4-10/h10H,1-4H2,(H,7,11)
SMILES Code
O=C(NCCO)N(CCCl)N=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Hemustine is an inhibitor of human glutathione reductase and widely used as an anti-tumor agent.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 195.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1. Eisenbrand G, Müller N, Denkel E, Sterzel W. DNA adducts and DNA damage by antineoplastic and carcinogenic N-nitrosocompounds. J Cancer Res Clin Oncol. 1986;112(3):196-204. doi:10.1007/BF00395912 2. Karplus PA, Krauth-Siegel RL, Schirmer RH, Schulz GE. Inhibition of human glutathione reductase by the nitrosourea drugs 1,3-bis(2-chloroethyl)-1-nitrosourea and 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea. A crystallographic analysis. Eur J Biochem. 1988;171(1-2):193-198. doi:10.1111/j.1432-1033.1988.tb13775.x

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