Guanine 7-oxide | CAS# 5227-68-9 | Antibiotic | Antitumor

MedKoo Cat#: 573183 | Name: Guanine 7-oxide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Guanine 7-oxide, also known as PD 113876, is an antibiotic isolated from Streptomyces sp. This antimetabolite has been shown to be active in vivo against L1210 lymphocytic leukemia.

Chemical Structure

Guanine 7-oxide

CAS#5227-68-9

Theoretical Analysis

MedKoo Cat#: 573183

Name: Guanine 7-oxide

CAS#: 5227-68-9

Chemical Formula: C5H5N5O2

Exact Mass: 167.0443

Molecular Weight: 167.13

Elemental Analysis: C, 35.93; H, 3.02; N, 41.91; O, 19.15

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Antibiotic 3780, Antibiotic PD 113876, Guanine 7-oxide

IUPAC/Chemical Name

6H-Purin-6-one, 2-amino-1,9-dihydro-, 7-oxide (9CI)

InChi Key

VWMKKTYDXHGESB-UHFFFAOYSA-N

InChi Code

1S/C5H5N5O2/c6-5-8-3-2(4(11)9-5)10(12)1-7-3/h1H,(H4,6,7,8,9,11)

SMILES Code

c12c(n(=O)c[nH]2)c(=O)[nH]c(n1)N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 167.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ogawa K, Nishii M, Inagaki J, Nohara F, Saito T, Itaya T, Fujii T. Purines. L. Synthesis and antileukemic activity of the antibiotic guanine 7-oxide and its 9-substituted derivatives. Chem Pharm Bull (Tokyo). 1992 Feb;40(2):343-50. Erratum in: Chem Pharm Bull (Tokyo) 1992 Jun;40(6):1673. PubMed PMID: 1606630. 2: Yamamoto K, Kitano T, Arai YT, Yoshii K, Hasobe M, Saneyoshi M. Inhibitory effect of a new antibiotic, guanine 7-N-oxide, on the replication of several RNA viruses. Antiviral Res. 1990 Sep;14(3):173-8. PubMed PMID: 1964374. 3: Jackson RC, Boritzki TJ, Besserer JA, Hamelehle KL, Shillis JL, Leopold WR, Fry DW. Biochemical pharmacology and experimental chemotherapy studies with guanine-7-oxide, a novel purine antibiotic. Adv Enzyme Regul. 1987;26:301-16. PubMed PMID: 3673707. 4: Kern DL, Hokanson GC, French JC, Dalley NK. Guanine-7-oxide, a novel antitumor antibiotic. J Antibiot (Tokyo). 1985 May;38(5):572-4. PubMed PMID: 3839496.