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MedKoo Cat#: 462841 | Name: U 86983

Description:

WARNING: This product is for research use only, not for human or veterinary use.

U 86983 is an antiproliferative 2-aminochromone.

Chemical Structure

U 86983
U 86983
CAS#130736-65-1

Theoretical Analysis

MedKoo Cat#: 462841

Name: U 86983

CAS#: 130736-65-1

Chemical Formula: C19H18N2O4

Exact Mass: 338.1267

Molecular Weight: 338.36

Elemental Analysis: C, 67.45; H, 5.36; N, 8.28; O, 18.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
U-86983;
IUPAC/Chemical Name
2-morpholino-8-(pyridin-3-ylmethoxy)-4H-chromen-4-one
InChi Key
XBWOPIBIKIFENU-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H18N2O4/c22-16-11-18(21-7-9-23-10-8-21)25-19-15(16)4-1-5-17(19)24-13-14-3-2-6-20-12-14/h1-6,11-12H,7-10,13H2
SMILES Code
O=C1C=C(N2CCOCC2)Oc3c1cccc3OCc4cnccc4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 338.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Erickson LA, Bonin PD, Wishka DG, Morris J, Dalga RJ, Williams DJ, Wilson GJ, Hoover JL, Simmons CA, Humphrey SJ, et al. In vitro and in vivo inhibition of rat vascular smooth muscle cell migration and proliferation by a 2-aminochromone U-86983. J Pharmacol Exp Ther. 1994 Oct;271(1):415-21. PMID: 7965742. 2: Labhasetwar V, Song C, Humphrey W, Shebuski R, Levy RJ. Arterial uptake of biodegradable nanoparticles: effect of surface modifications. J Pharm Sci. 1998 Oct;87(10):1229-34. doi: 10.1021/js980021f. PMID: 9758682. 3: Song LP, Yang J, Wang H, Sun HF, Tang LN, Wu L, Chang J, Song CX. [Influence of water-soluble additives on drug release kinetics from biodegradable poly(lactic-co-glycolic acid) matrix]. Yao Xue Xue Bao. 2005 Jun;40(6):557-62. Chinese. PMID: 16144325. 4: Song C, Labhasetwar V, Cui X, Underwood T, Levy RJ. Arterial uptake of biodegradable nanoparticles for intravascular local drug delivery: results with an acute dog model. J Control Release. 1998 Jul 31;54(2):201-11. doi: 10.1016/s0168-3659(98)00016-9. PMID: 9724907.