OABK | CAS31984862-48-7 | protein function switch

MedKoo Cat#: 561019 | Name: OABK

Description:

WARNING: This product is for research use only, not for human or veterinary use.

OABK is a small molecule switch that can be used to control protein activity. Genetic encoding of OABK using a pyrrolysyl tRNA synthetase/tRNACUA pair in mammalian cells enables the site-specific introduction of a small molecule-removable protecting group into the protein of interest. A phosphine-mediated Staudinger reduction is used to re-activate protein function.

Chemical Structure

OABK

CAS#1984862-48-7

Theoretical Analysis

MedKoo Cat#: 561019

Name: OABK

CAS#: 1984862-48-7

Chemical Formula: C14H20ClN5O4

Exact Mass:

Molecular Weight: 357.80

Elemental Analysis: C, 47.00; H, 5.63; Cl, 9.91; N, 19.57; O, 17.89Chemical Formula: C14H20ClN5O4 Exact Mass: 357.1204 Molecular Weight: 357.7950 Elemental Analysis: C, 47.00; H, 5.63; Cl, 9.91; N, 19.57; O, 17.89

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

OABK; ortho-azidobenzyloxycarbonyl-L-lysine hydrochloride

IUPAC/Chemical Name

N6-(((4-Azidobenzyl)oxy)carbonyl)-L-lysine hydrochloride

InChi Key

AQUASNYNCOKBBC-YDALLXLXSA-N

InChi Code

InChI=1S/C14H19N5O4.ClH/c15-12(13(20)21)3-1-2-8-17-14(22)23-9-10-4-6-11(7-5-10)18-19-16;/h4-7,12H,1-3,8-9,15H2,(H,17,22)(H,20,21);1H/t12-;/m0./s1

SMILES Code

N[C@@H](CCCCNC(OCC1=CC=C(N=[N+]=[N-])C=C1)=O)C(O)=O.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 357.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Small Molecule Control of Protein Function through Staudinger Reduction Ji Luo, Qingyang Liu, Kunihiko Morihiro, Alexander Deiters Nat Chem. Author manuscript; available in PMC 2017 Jan 25.Published in final edited form as: Nat Chem. 2016 Nov; 8(11): 1027–1034. Published online 2016 Jul 25. doi: 10.1038/nchem.2573 PMCID: PMC5119652 2: Approximate steady-state properties of lattices of interacting three-state enzyme molecules: a novel phase transition. T L Hill, L Stein Proc Natl Acad Sci U S A. 1979 Mar; 76(3): 1014–1017. PMCID: PMC383177