U 78518F | CAS#136604-19-8

MedKoo Cat#: 462839 | Name: U 78518F

Description:

WARNING: This product is for research use only, not for human or veterinary use.

U 78518F is a 21-aminosteroid lazaroid and a potent antioxidant.

Chemical Structure

U 78518F

CAS#136604-19-8

Theoretical Analysis

MedKoo Cat#: 462839

Name: U 78518F

CAS#: 136604-19-8

Chemical Formula: C25H37ClN4O2

Exact Mass: 460.2605

Molecular Weight: 461.05

Elemental Analysis: C, 65.13; H, 8.09; Cl, 7.69; N, 12.15; O, 6.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

U-78518F; U 78518F; U-78518E; U 78518E;

IUPAC/Chemical Name

2-((4-(3-(ethylamino)pyridin-2-yl)piperazin-1-yl)methyl)-2,5,7,8-tetramethylchroman-6-ol hydrochloride

InChi Key

JTNGSVGIECDKCP-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H36N4O2.ClH/c1-6-26-21-8-7-11-27-24(21)29-14-12-28(13-15-29)16-25(5)10-9-20-19(4)22(30)17(2)18(3)23(20)31-25;/h7-8,11,26,30H,6,9-10,12-16H2,1-5H3;1H

SMILES Code

CCNc1c(N2CCN(CC2)CC3(CCc4c(O3)c(C)c(C)c(O)c4C)C)nccc1.Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 461.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Tanigaki T, Suzuki Y, Heimer D, Sussman HH, Ross WG, Raffin TA. Attenuation of acute lung injury and oxygen radical production by the 21-aminosteroid, U-78518F. J Appl Physiol (1985). 1993 May;74(5):2155-60. doi: 10.1152/jappl.1993.74.5.2155. PMID: 8335543. 2: Sanchez-Ramos JR, Song S, Mash DC, Weiner WJ. 21-aminosteroids interact with the dopamine transporter to protect against 1-methyl-4-phenylpyridinium-induced neurotoxicity. J Neurochem. 1992 Jan;58(1):328-34. doi: 10.1111/j.1471-4159.1992.tb09314.x. PMID: 1727440. 3: Barnard ML, Gurdian S, Turrens JF. Activated polymorphonuclear leukocytes increase low-level chemiluminescence of isolated perfused rat lungs. J Appl Physiol (1985). 1993 Aug;75(2):933-9. doi: 10.1152/jappl.1993.75.2.933. PMID: 7693647. 4: Delaney JP, Bonsack M, Hall P. Intestinal radioprotection by two new agents applied topically. Ann Surg. 1992 Oct;216(4):417-21; discussion 421-2. doi: 10.1097/00000658-199210000-00004. PMID: 1417191; PMCID: PMC1242642. 5: Barnard ML, Gurdian S, Diep D, Ladd M, Turrens JF. Protein and amino acid oxidation is associated with increased chemiluminescence. Arch Biochem Biophys. 1993 Feb 1;300(2):651-6. doi: 10.1006/abbi.1993.1090. PMID: 8434945. 6: Kalra J, Mantha SV, Kumar P, Prasad K. Protective effects of lazaroids against oxygen-free radicals induced lysosomal damage. Mol Cell Biochem. 1994 Jul 27;136(2):125-9. doi: 10.1007/BF00926072. PMID: 7845365. 7: Niederau C, Schulz HU, Klonowski H. Lazaroids protect isolated rat pancreatic acinar cells against damage induced by free radicals. Pancreas. 1995 Aug;11(2):107-21. doi: 10.1097/00006676-199508000-00001. PMID: 7479666. 8: Hinzmann JS, McKenna RL, Pierson TS, Han F, Kezdy FJ, Epps DE. Interaction of antioxidants with depth-dependent fluorescence quenchers and energy transfer probes in lipid bilayers. Chem Phys Lipids. 1992 Sep;62(2):123-38. doi: 10.1016/0009-3084(92)90090-c. PMID: 1423807. 9: Truelove D, Shuaib A, Ijaz S, Richardson S, Kalra J. Superoxide dismutase, catalase, and U78517F attenuate neuronal damage in gerbils with repeated brief ischemic insults. Neurochem Res. 1994 Jun;19(6):665-71. doi: 10.1007/BF00967704. PMID: 8065523. 10: Singh JP, Bonin PD. Inhibition of proliferation of fibroblasts by lazaroids (21-aminosteroids). Life Sci. 1991;49(26):2053-8. doi: 10.1016/0024-3205(91)90648-u. PMID: 1749313. 11: Thomas PD, Mao GD, Rabinovitch A, Poznansky MJ. Inhibition of superoxide- generating NADPH oxidase of human neutrophils by lazaroids (21-aminosteroids and 2-methylaminochromans). Biochem Pharmacol. 1993 Jan 7;45(1):241-51. doi: 10.1016/0006-2952(93)90398-g. PMID: 8381005. 12: Kim RS, Zaborniak CL, Begleiter A, LaBella FS. Antiproliferative properties of aminosteroid antioxidants on cultured cancer cells. Cancer Lett. 1992 May 30;64(1):61-6. doi: 10.1016/0304-3835(92)90023-o. PMID: 1596879. 13: Rabinovitch A, Suarez-Pinzon WL, Strynadka K, Lakey JR, Rajotte RV. Human pancreatic islet beta-cell destruction by cytokines involves oxygen free radicals and aldehyde production. J Clin Endocrinol Metab. 1996 Sep;81(9):3197-202. doi: 10.1210/jcem.81.9.8784069. PMID: 8784069. 14: Rabinovitch A, Suarez WL, Thomas PD, Strynadka K, Simpson I. Cytotoxic effects of cytokines on rat islets: evidence for involvement of free radicals and lipid peroxidation. Diabetologia. 1992 May;35(5):409-13. doi: 10.1007/BF02342435. PMID: 1521720. 15: Rabinovitch A, Suarez WL, Power RF. Lazaroid antioxidant reduces incidence of diabetes and insulitis in nonobese diabetic mice. J Lab Clin Med. 1993 Apr;121(4):603-7. PMID: 8454942.