MedKoo Cat#: 574699 | Name: FOY-251 mesylate
Featured New

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FOY-251 is a metabolite of Camostat that acts as a pollen protease inhibitor for prevention and control of allergies.

Chemical Structure

FOY-251 mesylate
FOY-251 mesylate
CAS#71079-09-9 (mesylate)

Theoretical Analysis

MedKoo Cat#: 574699

Name: FOY-251 mesylate

CAS#: 71079-09-9 (mesylate)

Chemical Formula: C17H19N3O7S

Exact Mass: 409.0944

Molecular Weight: 409.41

Elemental Analysis: C, 49.87; H, 4.68; N, 10.26; O, 27.35; S, 7.83

Price and Availability

Size Price Availability Quantity
25mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
100mg USD 1,250.00 2 Weeks
200mg USD 1,950.00 2 Weeks
500mg USD 3,650.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
71079-09-9 (mesylate) 71079-09-9 (free base)
Synonym
FOY 251; FOY251; FOY-251; FOY-251 mesylate;
IUPAC/Chemical Name
4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]-benzeneacetic Acid Monomethanesulfonate
InChi Key
JXMOPIDYHUYOED-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H15N3O4.CH4O3S/c17-16(18)19-12-5-3-11(4-6-12)15(22)23-13-7-1-10(2-8-13)9-14(20)21;1-5(2,3)4/h1-8H,9H2,(H,20,21)(H4,17,18,19);1H3,(H,2,3,4)
SMILES Code
O=C(O)CC1=CC=C(OC(C2=CC=C(NC(N)=N)C=C2)=O)C=C1.CS(=O)(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 409.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Albarazanji K, Jennis M, Cavanaugh CR, Lang W, Singh B, Lanter JC, Lenhard JM, Hornby PJ. Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice. Am J Physiol Gastrointest Liver Physiol. 2019 May 1;316(5):G653-G667. doi: 10.1152/ajpgi.00404.2018. Epub 2019 Mar 28. PMID: 30920846; PMCID: PMC7054636. 2: Kosinsky Y, Peskov K, Stanski DR, Wetmore D, Vinetz J. Semi-Mechanistic Pharmacokinetic-Pharmacodynamic Model of Camostat Mesylate-Predicted Efficacy against SARS-CoV-2 in COVID-19. Microbiol Spectr. 2022 Apr 27;10(2):e0216721. doi: 10.1128/spectrum.02167-21. Epub 2022 Apr 12. PMID: 35412356; PMCID: PMC9047529. 3: Beckh K, Weidenbach H, Weidenbach F, Müller R, Adler G. Hepatic and pancreatic metabolism and biliary excretion of the protease inhibitor camostat mesilate. Int J Pancreatol. 1991 Nov-Dec;10(3-4):197-205. doi: 10.1007/BF02924157. PMID: 1787334. 4: Beckh K, Göke B, Müller R, Arnold R. Elimination of the low-molecular weight proteinase inhibitor camostate (FOY 305) and its degradation products by the rat liver. Res Exp Med (Berl). 1987;187(6):401-6. doi: 10.1007/BF01852177. PMID: 3441682. 5: Maekawa A, Kakizoe Y, Miyoshi T, Wakida N, Ko T, Shiraishi N, Adachi M, Tomita K, Kitamura K. Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension. J Hypertens. 2009 Jan;27(1):181-9. doi: 10.1097/hjh.0b013e328317a762. PMID: 19145783. 6: Shrimp JH, Kales SC, Sanderson PE, Simeonov A, Shen M, Hall MD. An Enzymatic TMPRSS2 Assay for Assessment of Clinical Candidates and Discovery of Inhibitors as Potential Treatment of COVID-19. bioRxiv [Preprint]. 2020 Aug 6:2020.06.23.167544. doi: 10.1101/2020.06.23.167544. Update in: ACS Pharmacol Transl Sci. 2020 Sep 07;3(5):997-1007. doi: 10.1021/acsptsci.0c00106. PMID: 32596694; PMCID: PMC7315994. 7: Shrimp JH, Kales SC, Sanderson PE, Simeonov A, Shen M, Hall MD. An Enzymatic TMPRSS2 Assay for Assessment of Clinical Candidates and Discovery of Inhibitors as Potential Treatment of COVID-19. ACS Pharmacol Transl Sci. 2020 Sep 7;3(5):997-1007. doi: 10.1021/acsptsci.0c00106. PMID: 33062952; PMCID: PMC7507803. 8: Chen J, Liu C, Shan W, Xiao Z, Guo H, Huang Y. Enhanced stability of oral insulin in targeted peptide ligand trimethyl chitosan nanoparticles against trypsin. J Microencapsul. 2015;32(7):632-41. doi: 10.3109/02652048.2015.1065920. Epub 2015 Sep 24. PMID: 26401551.