Bunaftine | CAS#32421-46-8

MedKoo Cat#: 535304 | Name: Bunaftine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bunaftine is a proposed antiarrhythmic that prolongs myocardial refractory period and stabilizes cell membranes.

Chemical Structure

Bunaftine

CAS#32421-46-8

Theoretical Analysis

MedKoo Cat#: 535304

Name: Bunaftine

CAS#: 32421-46-8

Chemical Formula: C21H30N2O

Exact Mass: 326.2358

Molecular Weight: 326.48

Elemental Analysis: C, 77.26; H, 9.26; N, 8.58; O, 4.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Bunaftine

IUPAC/Chemical Name

1-Naphthalenecarboxamide, N-butyl-N-(2-(diethylamino)ethyl)-

InChi Key

WWGZXRYELYWJBD-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H30N2O/c1-4-7-15-23(17-16-22(5-2)6-3)21(24)20-14-10-12-18-11-8-9-13-19(18)20/h8-14H,4-7,15-17H2,1-3H3

SMILES Code

O=C(C1=C2C=CC=CC2=CC=C1)N(CCCC)CCN(CC)CC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 326.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kimura T, Nakazawa M, Imai S. [Electrophysiological effects of bunaftine, an antiarrhythmic drug, on action potential characteristics in ventricular muscle preparations]. Nihon Yakurigaku Zasshi. 1986 Jul;88(1):1-7. Japanese. doi: 10.1254/fpj.88.1. PMID: 3093338. 2: Critelli G, Adinolfi L, Santinelli V, Ferro G, Perticone F, Rengo F. Aspetti elettrofisiologici dell'azione antiaritmica della bunaftine [Electrophysiological aspects of the anti-arrhythmic effect of bunaftine]. Boll Soc Ital Cardiol. 1976;21(11):2015-25. Italian. PMID: 1031629. 3: Moskalewski S, Thyberg J. Effects of bunaftine on morphology, microfilament integrity, and mitotic activity in cultured human fibroblasts and HeLa cells. Cell Tissue Res. 1984;236(1):107-15. doi: 10.1007/BF00216519. PMID: 6201280. 4: Caporicci D, Mori A, Maurizi G. Tachiaritmie sopraventricolari. Efficacia terapeutica della bunaftine somministrata in bolo rapido [Supraventricular tachyarrhythmias. Therapeutical efficiency of bunaftine administed in rapid bolus (author's transl)]. G Ital Cardiol. 1979;9(5):535-9. Italian. PMID: 478225. 5: Flouvat B, Roux A, Decourt S, Caron A. Etude pharmacocinétique d'un nouvel antiarythmique, la bunaftine, après administration unique par voie orale [Pharmacokinetics of a new antiarrhythmic drug, bunaftine, after oral administration (author's transl)]. Therapie. 1982 Mar-Apr;37(2):143-9. French. PMID: 7112484. 6: Critelli G, Santinelli V, Ferro G, Adinolfi L, Perna L, Perticone F. Azione della bunaftine sulla refrattarietà del miocardio ventricolare [Action of bunaftine on the refractoriness of the ventricular myocardium]. Boll Soc Ital Cardiol. 1977;22(11):1971-8. Italian. PMID: 754743. 7: Giannetto P, Casella G, Freni F, Pavia L, Siracusano L, Buttafarro A. Cardioversione farmacologica delle tachicardie parossistiche sopraventricolari e ventricolari con bunaftine. Contributo clinico di terapia pratica d'urgenza [Pharmacological cardioversion of paroxysmal supraventricular and ventricular tachycardias using bunaftine. Clinical contribution and practical emergency therapy]. Boll Soc Ital Cardiol. 1977;22(1):99-116. Italian. PMID: 911543. 8: Granato Corigliano G, Fiore N, Pollice U. Interazione di un antiaritmico (bunaftine) con miosina cardiaca [Interaction of an anti-arrhythmic drug (bunaftine) with cardiac myosin]. Boll Soc Ital Biol Sper. 1978 Nov 15;54(21):2075-7. Italian. PMID: 571726. 9: Alella A, Gattullo D, Losano G, Tazartes-Pesando O, Vacca G. Azione della bunaftine sulle aritmie atriali da aconitina nel cane [Effect of Bunaftine on the aconitine-induced atrial arrhythmias in the dog]. Arch Sci Med (Torino). 1976 Oct-Dec;133(4):371-80. Italian. PMID: 1023843. 10: Alella A, Bertin C, Gattullo D, Losano G, Vacca G. Azione della bunaftine sulla tachicardia ventricolare da aconitina nel cane [Effect of Bunaftine on the ventricular tachycardia due to aconitine in the dog]. Arch Sci Med (Torino). 1976 Oct-Dec;133(4):363-70. Italian. PMID: 1023842. 11: Castellucci A. Metabolic effects of bunaftine, a new antiarrhythmic agent: comparison with quinidine, ajmaline, procainamide, xylocaine and propranolol. Arzneimittelforschung. 1976 Feb;26(2):241-4. PMID: 947206. 12: Vegis D. La bunaftine nel trattamento delle aritmie [Bunaftine in the treatment of arrhythmias]. Cardiol Prat. 1975 Jan-Jun;26(1):29-36. Italian. PMID: 769979. 13: Grazi S, Romano S, Bonazzi O, Pozzoni L, Cavoretto D, Gardumi M, Sardella F. Effetti di un nuovo farmaco antiaritmico, la bunaftine, sulla conduzione intra- atriale, atrio-ventricolare ed intraventricolare dello stimolo [Effects of a new anti-arrhythmic drug, bunaftine, on intra-atrial, atrio-ventricular and intraventricular conduction of the stimulus]. Cardiol Prat. 1974 Jul- Sep;25(3):213-8. Italian. PMID: 4434374. 14: Botti G, Bonatti V, Finardi A, Lazzeroni E, Ghinelli L. Expérimentation clinique de l'action prophylactique et thérapeutique de la Bunaftine sur les arythmies de la phase aiguë de l'infarctus du myocarde [Clinical investigation into the prophylactic and therapeutic action of Bunaftine in arrhythmias at the acute stage of myocardial infarction (author's transl)]. Ann Cardiol Angeiol (Paris). 1976 May-Jun;25(3):223-8. French. PMID: 779585. 15: Critelli G, Rengo F, Adinolfi L, Santinelli V, Ferro G, Perticone F, Condorelli M. Action de la bunaftine sur la phase supernormale de l'excitabilité myocardique [Investigation of the action of bunaftine on the supranormal phase of myocardial excitability (author's transl)]. Ann Cardiol Angeiol (Paris). 1977 Mar-Apr;26(2):141-7. French. PMID: 900835. 16: Scibilia G, Bonatti V, Pavarani A, Tagliavini S, Botti G. Effetto sul fascio di His di una nuova sostanza antiaritmica: la bunaftine [Effect of a new antiarrhythmic drug, bunaftine, on the bundle of His]. Cardiol Prat. 1973;24(1):79-84. Italian. PMID: 4575451. 17: Calaresu I, Dedola MC, Pittalis M. Rilievi sull'efficacia clinica di un nuovo farmaco antiaritmico: la bunaftine [Studies on the clinical efficacy of a new antiarrhythmic agent: bunaftine]. Cardiol Prat. 1975 Jul-Dec;26(2):113-6. Italian. PMID: 1227718. 18: Artese D, Di Nicola A, Di Tomasso E, Santilli S. Sull'impiego della bunaftine nella terapia delle aritmie cardiache [Use of bunaftine in the therapy of cardiac arrhythmias]. Cardiol Prat. 1974 Oct-Dec;25(4):355-8. Italian. PMID: 4465044. 19: Guarini A, Amodio F, Rivetti L, Bonfiglio N. Esperienze cliniche nel trattamento dei disturbi del ritmo cardiaco con bunaftine (Meregon) [Clinical experiences in the treatment of arrhythmias with bunaftine (Meregon)]. Minerva Cardioangiol. 1975 Dec;23(12):932-6. Italian. PMID: 1232589. 20: De Cesare BL, Lovreglio V, Sannito N. Terapia medica delle aritmie nell'infarto miocardico. Risultati dell'impiego della bunaftine [Medical treatment of arrhythmias in myocardial infarct. Results of the use of bunaftine]. Minerva Med. 1976 Sep 1;67(40):2625-35. Italian. PMID: 967338.