MedKoo Cat#: 574682 | Name: Loxistatin Acid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Loxistatin Acid, also known as E-64c is a synthetic analog of E-64 -- a potent and irreversible cysteine protease inhibitor. E-64c inhibits the cysteine proteases cathepsin B and cathepsin L.

Chemical Structure

Loxistatin Acid
Loxistatin Acid
CAS#76684-89-4

Theoretical Analysis

MedKoo Cat#: 574682

Name: Loxistatin Acid

CAS#: 76684-89-4

Chemical Formula: C15H26N2O5

Exact Mass: 314.1842

Molecular Weight: 314.38

Elemental Analysis: C, 57.31; H, 8.34; N, 8.91; O, 25.45

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 600.00 2 Weeks
25mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
E-64c; E-64-c; e-64c; EP 475; EP475; EP-475; Loxistatin Acid; NSC 694279; NSC694279; NSC-694279;
IUPAC/Chemical Name
(2S,3S)-3-(((S)-1-(isopentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)oxirane-2-carboxylic acid
InChi Key
SCMSYZJDIQPSDI-NDQFZYFBSA-N
InChi Code
InChI=1S/C15H26N2O5/c1-8(2)5-6-16-13(18)10(7-9(3)4)17-14(19)11-12(22-11)15(20)21/h8-12H,5-7H2,1-4H3,(H,16,18)(H,17,19)(H,20,21)/t10-,11-,12?/m0/s1
SMILES Code
CC(C)CCNC([C@H](CC(C)C)NC([C@@H]1[C@@H](C(O)=O)O1)=O)=O
Appearance
A crystalline solid
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 314.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Drahl, C., Cravatt, B.F., and Sorensen, E.J. Protein-reactive natural products. Angew. Chem. Int. Ed. Engl. 44(36), 5788-5809 (2005). 2. Shoji, Y., Senshu, M., Iwashita, S., et al. Thiol protease-specific inhibitor E-64 arrests human epidermoid carcinoma A431 cells at mitotic metaphase. Proc. Natl. Acad. Sci. U.S.A. 85, 146-150 (1988).