MC-352 | CAS#127521-69-1

MedKoo Cat#: 462730 | Name: MC-352

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MC-352, also known as 3,4'-Dideoxy-5O-mycaminosyltylonolide, is a 16-membered macrolide antibiotic.

Chemical Structure

MC-352

CAS#127521-69-1

Theoretical Analysis

MedKoo Cat#: 462730

Name: MC-352

CAS#: 127521-69-1

Chemical Formula: C31H51NO8

Exact Mass: 565.3615

Molecular Weight: 565.75

Elemental Analysis: C, 65.81; H, 9.09; N, 2.48; O, 22.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

MC-352; MC352; MC 352;

IUPAC/Chemical Name

2-((5S,6R,7R,9R,11E,13Z,15R,16R)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-16-ethyl-15-(hydroxymethyl)-5,9,13-trimethyl-2,10-dioxooxacyclohexadeca-11,13-dien-7-yl)acetaldehyde

InChi Key

IBYMOKAONAMZRG-RTBKVJJVSA-N

InChi Code

InChI=1S/C31H51NO8/c1-8-27-24(18-34)15-19(2)9-11-26(35)21(4)16-23(13-14-33)30(20(3)10-12-28(36)39-27)40-31-29(37)25(32(6)7)17-22(5)38-31/h9,11,14-15,20-25,27,29-31,34,37H,8,10,12-13,16-18H2,1-7H3/b11-9+,19-15-/t20-,21+,22+,23-,24+,25-,27+,29+,30+,31-/m0/s1

SMILES Code

CC[C@H]1OC(CC[C@@H]([C@H]([C@H](C[C@H](C(/C=C/C(C)=C\[C@@H]1CO)=O)C)CC=O)O[C@@H]2O[C@@H](C[C@H](N(C)C)[C@H]2O)C)C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 565.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kageyama S, Tsuchiya T, Umezawa S, Takeuchi T. Synthesis of 3,4'-dideoxymycaminosyl tylonolide, a novel type of macrolide derivative. J Antibiot (Tokyo). 1992 Jan;45(1):144-6. doi: 10.7164/antibiotics.45.144. PMID: 1548187. 2: Chin NX, Neu HC. In vitro activity of MC-352, a new 16-membered macrolide. Antimicrob Agents Chemother. 1992 Aug;36(8):1699-702. doi: 10.1128/aac.36.8.1699. PMID: 1416853; PMCID: PMC192033. 3: Kageyama S, Tsuchiya T. Synthesis of 2-C-methyl derivatives of 3,4'-dideoxymycaminosyltylonolide, a novel type of 16-membered macrolide antibiotic. J Antibiot (Tokyo). 1994 Aug;47(8):955-6. doi: 10.7164/antibiotics.47.955. PMID: 7928687.