MedKoo Cat#: 574663 | Name: Diazoxon

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diazoxon is the oxidized form of Diazinon -- an organophosphate insecticide. Diazoxon is shown to be a more potent acetylcholinesterase (AChE) inhibitor.

Chemical Structure

Diazoxon
CAS#962-58-3

Theoretical Analysis

MedKoo Cat#: 574663

Name: Diazoxon

CAS#: 962-58-3

Chemical Formula: C12H21N2O4P

Exact Mass: 288.1239

Molecular Weight: 288.28

Elemental Analysis: C, 50.00; H, 7.34; N, 9.72; O, 22.20; P, 10.74

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Synonym
Diazoxon; Diazinon Oxon; Oxodiazinon; diazinon-oxon;
IUPAC/Chemical Name
Phosphoric Acid Diethyl 6-methyl-2-(1-methylethyl)-4-pyrimidinyl Ester
InChi Key
VBLJFQYCTRKKKF-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H21N2O4P/c1-6-16-19(15,17-7-2)18-11-8-10(5)13-12(14-11)9(3)4/h8-9H,6-7H2,1-5H3
SMILES Code
O=P(OCC)(OC1=NC(C(C)C)=NC(C)=C1)OCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 288.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1.Mehrani H, Golmanesh L. Changes in mRNA and protein levels of nicotinic acetylcholine receptors in Diazoxon exposed pC12 cells. Toxicol In Vitro. 2008;22(5):1257-1263. doi:10.1016/j.tiv.2008.04.013 2. Mehrani H, Golmanesh L. Changes in mRNA and protein levels of nicotinic acetylcholine receptors in Diazoxon exposed pC12 cells. Toxicol In Vitro. 2008;22(5):1257-1263. doi:10.1016/j.tiv.2008.04.013 3. Sachana M, Sidiropoulou E, Flaskos J, et al. Diazoxon disrupts the expression and distribution of βIII-tubulin and MAP 1B in differentiating N2a cells. Basic Clin Pharmacol Toxicol. 2014;114(6):490-496. doi:10.1111/bcpt.12192