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MedKoo Cat#: 574638 | Name: (R)-Colchicine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

(R)-Colchicine is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. (R)-Colchicine stimulates the intrinsic GTPase activity of tubulin and induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

Chemical Structure

(R)-Colchicine
(R)-Colchicine
CAS#75520-89-7 （R isomer)

Theoretical Analysis

MedKoo Cat#: 574638

Name: (R)-Colchicine

CAS#: 75520-89-7 （R isomer)

Chemical Formula: C22H25NO6

Exact Mass: 399.1682

Molecular Weight: 399.44

Elemental Analysis: C, 66.15; H, 6.31; N, 3.51; O, 24.03

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
64-86-8 (S isomer) 75520-89-7 （R isomer) 209810-38-8
Synonym
(R)-Colchicine; (+)-Colchicine
IUPAC/Chemical Name
(R)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
InChi Key
IAKHMKGGTNLKSZ-MRXNPFEDSA-N
InChi Code
InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m1/s1
SMILES Code
CC(N[C@@H](C1=C2)CCC3=CC(OC)=C(OC)C(OC)=C3C1=CC=C(OC)C2=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 399.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1.Alkadi H, Khubeiz MJ, Jbeily R. Colchicine: A Review on Chemical Structure and Clinical Usage. Infect Disord Drug Targets. 2018;18(2):105-121. doi:10.2174/1871526517666171017114901