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MedKoo Cat#: 574632 | Name: Clanobutin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clanobutin inhibits gluconeogenesis and acts as a choleretic and digestion-stimulating agent.

Chemical Structure

Clanobutin
Clanobutin
CAS#30544-61-7 (free acid)

Theoretical Analysis

MedKoo Cat#: 574632

Name: Clanobutin

CAS#: 30544-61-7 (free acid)

Chemical Formula: C18H18ClNO4

Exact Mass: 347.0924

Molecular Weight: 347.79

Elemental Analysis: C, 62.16; H, 5.22; Cl, 10.19; N, 4.03; O, 18.40

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Related CAS #
74755-21-8 (sodium) 30544-61-7 (free acid)
Synonym
Clanobutin; Bykahepar; Clanobutine;
IUPAC/Chemical Name
4-[(4-Chlorobenzoyl)(4-methoxyphenyl)amino]-butanoic Acid
InChi Key
VUPBWNXFSDRWJE-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H18ClNO4/c1-24-16-10-8-15(9-11-16)20(12-2-3-17(21)22)18(23)13-4-6-14(19)7-5-13/h4-11H,2-3,12H2,1H3,(H,21,22)
SMILES Code
O=C(O)CCCN(C(C1=CC=C(Cl)C=C1)=O)C2=CC=C(OC)C=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 347.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Jansen JW, De Pont JJ, Bonting SL, Hotz J, Goebell H. Effects of clanobutin on pancreatic secretion in vitro. Eur J Pharmacol. 1981 Sep 24;74(4):319-27. doi: 10.1016/0014-2999(81)90051-0. PMID: 6170519. 2: Berchtold P, Paumgartner G, Preisig R. Die Wirkung von Clanobutin auf die Gallensekretion bei Ratte und Hund [The effect of clanobutin on bile excretion in rat and dog (author's transl)]. Arzneimittelforschung. 1980;30(11):1878-84. German. PMID: 7192997. 3: Park JA, Abd El-Aty AM, Zheng W, Kim SK, Cho SH, Choi JM, Hacımüftüo A, Jeong JH, Wang J, Shim JH, Shin HC. Simultaneous determination of clanobutin, dichlorvos, and naftazone in pork, beef, chicken, milk, and egg using liquid chromatography-tandem mass spectrometry. Food Chem. 2018 Jun 30;252:40-48. doi: 10.1016/j.foodchem.2018.01.085. Epub 2018 Jan 12. Erratum in: Food Chem. 2018 Jul 15;254:390. Hacımüftüo, Ahmet [corrected to Hacımüftüoğlu, Ahmet]. PMID: 29478562. 4: Strugala G, Overhoff H, Forth W. Absorption of 14C-clanobutin-Na isolated perfused intestinal segments in vitro of rats. Arzneimittelforschung. 1981;31(3):429-33. PMID: 7194668. 5: Symonds HW. The choleretic effect of menbutone and clanobutin sodium in steers. Vet Rec. 1982 May 1;110(18):423-5. doi: 10.1136/vr.110.18.423. PMID: 7090158. 6: Park JA, Abd El-Aty AM, Zheng W, Kim SK, Cho SH, Choi JM, Hacımüftüoğlu A, Jeong JH, Wang J, Shim JH, Shin HC. Corrigendum to "Simultaneous determination of clanobutin, dichlorvos, and naftazone in pork, beef, chicken, milk, and egg using liquid chromatography-tandem mass spectrometry" [Food Chem. 252C (2018) 40-48]. Food Chem. 2018 Jul 15;254:390. doi: 10.1016/j.foodchem.2018.02.083. Epub 2018 Feb 26. Erratum for: Food Chem. 2018 Jun 30;252:40-48. PMID: 29548468. 7: Overhoff H, Strugala G, Forth W. Absorption of 14C-clanobutin-Na in blood- perfused tied-off jejunal segments in vivo of rats. Arzneimittelforschung. 1981;31(4):670-4. PMID: 7195713. 8: Immelman A, Button C, Dreyer G. The choleretic action of clanobutin in dogs. J S Afr Vet Assoc. 1981 Dec;52(4):295-8. PMID: 7341779. 9: Sonnenberg A, Blum AL. Cell turnover of the gastric mucosa is reduced by clanobutin. Acta Hepatogastroenterol (Stuttg). 1979 Dec;26(6):469-71. PMID: 549428. 10: Hegner D, Kroker R, Anwer MS. Der Einfluss von Clanobutin auf die Gallesekretion der isoliert perfundierten Rattenleber [The influence of clanobutin on bile secretion in the isolated perfused rat liver (author's transl)]. Arzneimittelforschung. 1979;29(1):11-5. German. PMID: 220989. 11: Baumgartner W, Königsdorfer W, Hahn E. Experimentelle Untersuchungen über den Einfluss von oralen Clanobutin-Gaben auf die Sekretionsrate von Verdauungssäften beim Kalb [Experimental studies of the effect of oral clanobutin administration on the secretion rate of digestive fluids in the calf]. Dtsch Tierarztl Wochenschr. 1983 May 6;90(5):163-6. German. PMID: 6347603. 12: Klemm K, Krastinat W, Krüger U. Synthese und physikalisch-chemische Eigenschaften von Clanobutin [Synthesis and physico-chemical parameters of clanobutin (author's transl)]. Arzneimittelforschung. 1979;29(1):1-2. German. PMID: 582102. 13: Sterczer A, Vörös K, Karsai F. Effect of cholagogues on the volume of the gallbladder of dogs. Res Vet Sci. 1996 Jan;60(1):44-7. doi: 10.1016/s0034-5288(96)90129-0. PMID: 8745254. 14: Klemm K, Krüger U. In-vitro-Methode zur Abschätzung der enteralen Absorption von Clanobutin und anderen Pharmaka [In vitro method for estimation of enteral absorption of clanobutin and other drugs]. Arzneimittelforschung. 1979;29(1):2-11. German. PMID: 36106. 15: Karatzias H, Roubies N, Papasteriadis A, Papadopoulos N. Untersuchungen über die Wirksamkeit von Clanobutin) zur Vorbeuge der postpartalen primären Ketose bei Milchkühen [The effectiveness of clanobutin for the prevention of postpartum primary ketosis in dairy cows]. Dtsch Tierarztl Wochenschr. 1993 Oct;100(10):410-2. German. PMID: 8261909. 16: Wolf H, Schlepper J, Steinijans V, Scholz R. Inhibition of gluconeogenesis in isolated perfused rat liver by clanobutin. Biochem Pharmacol. 1980 Jun 15;29(12):1649-52. doi: 10.1016/0006-2952(80)90119-7. PMID: 7406894. 17: Ayala I, Rodríguez MJ, Martos N, Zilberschtein J, Ruíz I. Nonfatal splenic haematoma and pancytopenia in an ass. Aust Vet J. 2004 Aug;82(8):479-80. doi: 10.1111/j.1751-0813.2004.tb11162.x. PMID: 15359962. 18: Reiczigel J. Analysis of experimental data with repeated measurements. Biometrics. 1999 Dec;55(4):1059-63. doi: 10.1111/j.0006-341x.1999.01059.x. PMID: 11315048. 19: Hengst K, Hossdorf T, Wagner H, Gerlach U. Zur Wirkung von Clanobutin auf die Ulkus-Entstehung bei der Ratte im Immobilisationsstress [On the influence of clanobutine on the formation of restraint ulcer in rats (author's transl)]. Arzneimittelforschung. 1979;29(11):1701-4. German. PMID: 543879. 20: Juhász B. Zur Entwicklung des Pankreas beim Ferkel, seine Enzymproduktion und die Beeinflussbarkeit durch Bykahepar [On the development of the piglet's pancreas, its enzyme production and the possible influences of Bykahepar (author's transl)]. Dtsch Tierarztl Wochenschr. 1980 Dec 5;87(12):445-9. German. PMID: 6161772.

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Phosacetim

Phosacetim