MedKoo Cat#: 462560 | Name: AZ82
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor.

Chemical Structure

AZ82
AZ82
CAS#1449578-65-7

Theoretical Analysis

MedKoo Cat#: 462560

Name: AZ82

CAS#: 1449578-65-7

Chemical Formula: C28H31F3N4O3S

Exact Mass: 560.2069

Molecular Weight: 560.64

Elemental Analysis: C, 59.99; H, 5.57; F, 10.17; N, 9.99; O, 8.56; S, 5.72

Price and Availability

Size Price Availability Quantity
5mg USD 385.00 2 Weeks
10mg USD 715.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
AZ82; AZ-82; AZ 82
IUPAC/Chemical Name
5-methyl-N-((R)-1-oxo-1-(((R)-pyrrolidin-3-yl)amino)-3-(6-(3-(trifluoromethoxy)phenyl)pyridin-3-yl)propan-2-yl)-4-propylthiophene-2-carboxamide
InChi Key
PMTLKNOARSHUJB-ZJSXRUAMSA-N
InChi Code
InChI=1S/C28H31F3N4O3S/c1-3-5-19-14-25(39-17(19)2)27(37)35-24(26(36)34-21-10-11-32-16-21)12-18-8-9-23(33-15-18)20-6-4-7-22(13-20)38-28(29,30)31/h4,6-9,13-15,21,24,32H,3,5,10-12,16H2,1-2H3,(H,34,36)(H,35,37)/t21-,24-/m1/s1
SMILES Code
O=C(C1=CC(CCC)=C(C)S1)N[C@H](CC2=CC=C(C3=CC=CC(OC(F)(F)F)=C3)N=C2)C(N[C@H]4CNCC4)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 560.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Godinho SA, Pellman D. Causes and consequences of centrosome abnormalities in cancer. Philos Trans R Soc Lond B Biol Sci. 2014;369(1650):20130467. doi:10.1098/rstb.2013.0467 2: Wu J, Mikule K, Wang W, et al. Discovery and mechanistic study of a small molecule inhibitor for motor protein KIFC1. ACS Chem Biol. 2013;8(10):2201-2208. doi:10.1021/cb400186w