RO7101556 | CAS#N/A

MedKoo Cat#: 535221 | Name: RO7101556

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RO7101556 is a novel potent γ-secretase modulator (GSM) with high solubility, balanced lipophilicity, and showing no phototoxicity and PIK4CB side bing activity.

Chemical Structure

RO7101556

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 535221

Name: RO7101556

CAS#: N/A

Chemical Formula: C19H22F3N7O2

Exact Mass: 437.1787

Molecular Weight: 437.43

Elemental Analysis: C, 52.17; H, 5.07; F, 13.03; N, 22.41; O, 7.32

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

RO7101556; RO-7101556; RO 7101556

IUPAC/Chemical Name

N-((1R,5S,8s)-3-(5-Methyl-1,3,4-oxadiazol-2-yl)-3-azabicyclo[3.2.1]octan-8-yl)-8-(((R)-1,1,1-trifluoropropan-2-yl)oxy)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

InChi Key

PYPNIGUSVUTKEM-IKVITTDRSA-N

InChi Code

InChI=1S/C19H22F3N7O2/c1-10(19(20,21)22)30-14-4-3-7-29-16(14)24-17(27-29)23-15-12-5-6-13(15)9-28(8-12)18-26-25-11(2)31-18/h3-4,7,10,12-13,15H,5-6,8-9H2,1-2H3,(H,23,27)/t10-,12-,13+,15-/m1/s1

SMILES Code

C[C@@H](OC1=CC=CN2C1=NC(N[C@@H]3[C@@]4([H])CN(C5=NN=C(C)O5)C[C@]3([H])CC4)=N2)C(F)(F)F

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 437.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Rodriguez Sarmiento RM, Bissantz C, Bylund J, Limberg A, Neidhart W, Jakob- Roetne R, Wang L, Baumann K. Stepwise Design of γ-Secretase Modulators with Advanced Profile by Judicious Coordinated Structural Replacements and an Unconventional Phenyl Ring Bioisostere. J Med Chem. 2020 Jul 24. doi: 10.1021/acs.jmedchem.0c00909. Epub ahead of print. PMID: 32706964.