Rineterkib, also known as LTT-462 or ERK-IN-1, is a ERK1/2 inhibitor which has demonstrated preclinical activity in multiple MAPK activated cancer cells and xenograft models. LTT462 binds to and inhibits ERK, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated in numerous tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival.
MedKoo Cat#: 462502
Name: Rineterkib free base
CAS#: 1715025-32-3 (free base)
Chemical Formula: C26H27BrF3N5O2
Exact Mass: 577.1300
Molecular Weight: 578.43
Elemental Analysis: C, 53.99; H, 4.71; Br, 13.81; F, 9.85; N, 12.11; O, 5.53
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 0.0 | 0.00 |
The following data is based on the product molecular weight 578.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
