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MedKoo Cat#: 535182 | Name: Avotaciclib

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Avotaciclib, also known as BEY-1107, is potent, orally bioavailable CDK1 inhibitor. BEY1107 targets, binds to and inhibits the activity of CDK1. This may inhibit cancer stem cell (CSC) division, cause cell cycle arrest, and induce apoptosis. This may inhibit tumor cell proliferation.

Chemical Structure

Avotaciclib
Avotaciclib
CAS#1983983-41-0 (free base)

Theoretical Analysis

MedKoo Cat#: 535182

Name: Avotaciclib

CAS#: 1983983-41-0 (free base)

Chemical Formula: C13H11N7O

Exact Mass: 281.1025

Molecular Weight: 281.28

Elemental Analysis: C, 55.51; H, 3.94; N, 34.86; O, 5.69

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1983984-01-5 (3HCl) 1983983-41-0 (free base) 1983984-04-8 (sulfate) 2451957-59-6 (2HCl)
Synonym
Avotaciclib, BEY-1107; BEY 1107; BEY1107;
IUPAC/Chemical Name
2,6-bis(2-aminopyrimidin-4-yl)pyridin-3-ol
InChi Key
VFVAQKKPFOPZEA-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H11N7O/c14-12-16-5-3-8(19-12)7-1-2-10(21)11(18-7)9-4-6-17-13(15)20-9/h1-6,21H,(H2,14,16,19)(H2,15,17,20)
SMILES Code
OC1=CC=C(C2=NC(N)=NC=C2)N=C1C3=NC(N)=NC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
CDK1, an ATP-dependent serine/threonine kinase, plays a key role in regulating cell division, cell cycle progression and proliferation. It is frequently overexpressed in tumor cells.

Preparing Stock Solutions

The following data is based on the product molecular weight 281.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL