CP-547632 hydrochloride | CAS#252003-71-7 | VEGFR-2 inhibitor

MedKoo Cat#: 462490 | Name: CP-547632 hydrochloride

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CP-547632 hydrochloride is a well-tolerated, orally-bioavailable inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases. It has antitumor efficacy.

Chemical Structure

CP-547632 hydrochloride

CAS#252003-71-7 (HCl)

Theoretical Analysis

MedKoo Cat#: 462490

Name: CP-547632 hydrochloride

CAS#: 252003-71-7 (HCl)

Chemical Formula: C20H25BrClF2N5O3S

Exact Mass: 567.0518

Molecular Weight: 568.86

Elemental Analysis: C, 42.23; H, 4.43; Br, 14.05; Cl, 6.23; F, 6.68; N, 12.31; O, 8.44; S, 5.64

Price and Availability

Size	Price	Availability
10mg	USD 350.00	2 Weeks
25mg	USD 650.00	2 Weeks
50mg	USD 1,050.00	2 Weeks

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Related CAS #

252003-65-9 (free base) 252003-71-7 (HCl)

Synonym

CP-547632 hydrochloride; CP 547632 hydrochloride; CP547632 hydrochloride; PF-01371182 hydrochloride; PF-01371182 HCl; PF 01371182 HCl; PF01371182 HCl;

IUPAC/Chemical Name

3-((4-bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide hydrochloride

InChi Key

NNPJZJJMQDXYGN-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H24BrF2N5O3S.ClH/c21-12-9-14(22)13(15(23)10-12)11-31-18-16(17(24)29)19(32-27-18)26-20(30)25-5-1-2-6-28-7-3-4-8-28;/h9-10H,1-8,11H2,(H2,24,29)(H2,25,26,30);1H

SMILES Code

O=C(NC1=C(C(N)=O)C(OCC2=C(F)C=C(Br)C=C2F)=NS1)NCCCCN3CCCC3.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 568.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Beebe JS, Jani JP, Knauth E, et al. Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy. Cancer Res. 2003;63(21):7301-7309.