J22352 is a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor. J22352 promotes HDAC6 degradation and induces anticancer effects by inhibiting autophagy and eliciting the antitumor immune response in glioblastoma cancers, and leading to the restoration of host antitumor activity by reducing the immunosuppressive activity of PD-L1.
MedKoo Cat#: 462481
Name: J22352
CAS#: 2252395-44-9
Chemical Formula: C24H21N3O4
Exact Mass: 415.1532
Molecular Weight: 415.45
Elemental Analysis: C, 69.39; H, 5.10; N, 10.11; O, 15.40
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 125.0 | 300.88 |
The following data is based on the product molecular weight 415.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
