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MedKoo Cat#: 535123 | Name: Isof

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isof is a bioactive chemical.

Chemical Structure

Isof
Isof
CAS#851705-46-9

Theoretical Analysis

MedKoo Cat#: 535123

Name: Isof

CAS#: 851705-46-9

Chemical Formula: C25H33FN2O4

Exact Mass: 444.2424

Molecular Weight: 444.55

Elemental Analysis: C, 67.55; H, 7.48; F, 4.27; N, 6.30; O, 14.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Isof
IUPAC/Chemical Name
N-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-2-(2-fluoroethoxy)-5-methylbenzamide
InChi Key
QVRVXSZKCXFBTE-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H33FN2O4/c1-18-6-7-22(32-13-9-26)21(14-18)25(29)27-10-4-5-11-28-12-8-19-15-23(30-2)24(31-3)16-20(19)17-28/h6-7,14-16H,4-5,8-13,17H2,1-3H3,(H,27,29)
SMILES Code
O=C(NCCCCN1CC2=C(C=C(OC)C(OC)=C2)CC1)C3=CC(C)=CC=C3OCCF
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 444.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liang X, Wang J, Chen W, Ma X, Wang Y, Nagao N, Weng W, Huang J, Liu J. Inhibition of airway remodeling and inflammation by isoforskolin in PDGF-induced rat ASMCs and OVA-induced rat asthma model. Biomed Pharmacother. 2017 Nov;95:275-286. doi: 10.1016/j.biopha.2017.08.063. Epub 2017 Sep 12. PMID: 28850927. 2: Svegliati-Baroni G, Pierantonelli I, Torquato P, Marinelli R, Ferreri C, Chatgilialoglu C, Bartolini D, Galli F. Lipidomic biomarkers and mechanisms of lipotoxicity in non-alcoholic fatty liver disease. Free Radic Biol Med. 2019 Nov 20;144:293-309. doi: 10.1016/j.freeradbiomed.2019.05.029. Epub 2019 May 29. PMID: 31152791. 3: Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S4-9. doi: 10.1093/gerona/glu057. PMID: 24833586. 4: Venturi M, D'Angelantonio M. Editorial. Top Curr Chem (Cham). 2017 Feb;375(1):11. doi: 10.1007/s41061-016-0094-3. PMID: 28070863. 5: Zhao H, Liu A, Shen L, Xu C, Zhu Z, Yang J, Han X, Bao F, Yang W. Isoforskolin downregulates proinflammatory responses induced by Borrelia burgdorferi basic membrane protein A. Exp Ther Med. 2017 Dec;14(6):5974-5980. doi: 10.3892/etm.2017.5300. Epub 2017 Oct 13. PMID: 29285146; PMCID: PMC5740510. 6: Rund KM, Ostermann AI, Kutzner L, Galano JM, Oger C, Vigor C, Wecklein S, Seiwert N, Durand T, Schebb NH. Development of an LC-ESI(-)-MS/MS method for the simultaneous quantification of 35 isoprostanes and isofurans derived from the major n3- and n6-PUFAs. Anal Chim Acta. 2018 Dec 11;1037:63-74. doi: 10.1016/j.aca.2017.11.002. Epub 2017 Nov 14. PMID: 30292316. 7: González-Méndez R, Watts P, Howse DC, Procino I, McIntyre H, Mayhew CA. Ion Mobility Studies on the Negative Ion-Molecule Chemistry of Isoflurane and Enflurane. J Am Soc Mass Spectrom. 2017 May;28(5):939-946. doi: 10.1007/s13361-017-1616-0. Epub 2017 Feb 21. PMID: 28224395; PMCID: PMC5393067. 8: Buddrus-Schiemann K, Rieger M, Mühlbauer M, Barbarossa MV, Kuttler C, Hense BA, Rothballer M, Uhl J, Fonseca JR, Schmitt-Kopplin P, Schmid M, Hartmann A. Analysis of N-acylhomoserine lactone dynamics in continuous cultures of Pseudomonas putida IsoF by use of ELISA and UHPLC/qTOF-MS-derived measurements and mathematical models. Anal Bioanal Chem. 2014 Oct;406(25):6373-83. doi: 10.1007/s00216-014-8063-6. Epub 2014 Aug 13. PMID: 25116602. 9: Fekete A, Kuttler C, Rothballer M, Hense BA, Fischer D, Buddrus-Schiemann K, Lucio M, Müller J, Schmitt-Kopplin P, Hartmann A. Dynamic regulation of N-acyl- homoserine lactone production and degradation in Pseudomonas putida IsoF. FEMS Microbiol Ecol. 2010 Apr;72(1):22-34. doi: 10.1111/j.1574-6941.2009.00828.x. Epub 2010 Jan 10. PMID: 20100181. 10: Ferroni C, Del Rio A, Martini C, Manoni E, Varchi G. Light-Induced Therapies for Prostate Cancer Treatment. Front Chem. 2019 Oct 29;7:719. doi: 10.3389/fchem.2019.00719. PMID: 31737599; PMCID: PMC6828976. 11: Arevalo-Ferro C, Reil G, Görg A, Eberl L, Riedel K. Biofilm formation of Pseudomonas putida IsoF: the role of quorum sensing as assessed by proteomics. Syst Appl Microbiol. 2005 Mar;28(2):87-114. doi: 10.1016/j.syapm.2004.10.005. PMID: 15830802. 12: Fabini E, Manoni E, Ferroni C, Rio AD, Bartolini M. Small-molecule inhibitors of lysine methyltransferases SMYD2 and SMYD3: current trends. Future Med Chem. 2019 Apr;11(8):901-921. doi: 10.4155/fmc-2018-0380. Epub 2019 Apr 18. PMID: 30998113. 13: Tang F, Xu F, Cui L, Huang W, Jiang L, Chen L, Yan W, He W, Shen C, Huang H, Lv J, Zhao X, Zeng S, Li M, Ouyang Y, Guo X, Zhong H, Zhang M. The expression and role of PIDD in retina after optic nerve crush. J Mol Histol. 2020 Feb;51(1):89-97. doi: 10.1007/s10735-020-09860-1. Epub 2020 Feb 17. PMID: 32065357. 14: Du X, Shi R, Wang Y, Wu W, Sun S, Dai Z, Chen C, Weng Z, Li X, Liu Q, Zhang L, Saidian M, Yang W. Isoforskolin and forskolin attenuate lipopolysaccharide- induced inflammation through TLR4/MyD88/NF-κB cascades in human mononuclear leukocytes. Phytother Res. 2019 Mar;33(3):602-609. doi: 10.1002/ptr.6248. Epub 2019 Jan 14. PMID: 30637903; PMCID: PMC6590664. 15: Li X, Nie L, Yang W, Chen Z, Wang X, Luo L. [Suppressing effect of isoforskolin and forskolin on ocular hypertension in rabbits]. Zhonghua Yan Ke Za Zhi. 2000 Jul;36(4):292-4. Chinese. PMID: 11853618. 16: Alkazemi D, Egeland GM, Roberts LJ 2nd, Chan HM, Kubow S. New insights regarding tissue Se and Hg interactions on oxidative stress from plasma IsoP and IsoF measures in the Canadian Inuit population. J Lipid Res. 2013 Jul;54(7):1972-9. doi: 10.1194/jlr.M033068. Epub 2013 May 13. PMID: 23670530; PMCID: PMC3679398. 17: Steidle A, Allesen-Holm M, Riedel K, Berg G, Givskov M, Molin S, Eberl L. Identification and characterization of an N-acylhomoserine lactone-dependent quorum-sensing system in Pseudomonas putida strain IsoF. Appl Environ Microbiol. 2002 Dec;68(12):6371-82. doi: 10.1128/aem.68.12.6371-6382.2002. PMID: 12450862; PMCID: PMC134430. 18: Hanikoglu A, Kucuksayan E, Hanikoglu F, Ozben T, Menounou G, Sansone A, Chatgilialoglu C, Di Bella G, Ferreri C. Effects of Somatostatin and Vitamin C on the Fatty Acid Profile of Breast Cancer Cell Membranes. Anticancer Agents Med Chem. 2019;19(15):1899-1909. doi: 10.2174/1871520619666190930130732. PMID: 31566138. 19: Martella E, Ferroni C, Guerrini A, Ballestri M, Columbaro M, Santi S, Sotgiu G, Serra M, Donati DM, Lucarelli E, Varchi G, Duchi S. Functionalized Keratin as Nanotechnology-Based Drug Delivery System for the Pharmacological Treatment of Osteosarcoma. Int J Mol Sci. 2018 Nov 20;19(11):3670. doi: 10.3390/ijms19113670. PMID: 30463350; PMCID: PMC6274803. 20: Corcoran TB, Barden AE, Mas E, Grape S, Koren V, Phillips M, Roberts LJ 2nd, Mori TA. Hemoglobin attenuates the effects of inspired oxygen on plasma isofurans in humans during upper-limb surgery. Free Radic Biol Med. 2011 Sep 15;51(6):1235-9. doi: 10.1016/j.freeradbiomed.2011.06.026. Epub 2011 Jun 27. PMID: 21763419; PMCID: PMC3157081.

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