MedKoo Cat#: 592955 | Name: Isoetharine hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isoetharine hydrochloride is a Bronchodilator.

Chemical Structure

Isoetharine hydrochloride
Isoetharine hydrochloride
CAS#2576-92-3

Theoretical Analysis

MedKoo Cat#: 592955

Name: Isoetharine hydrochloride

CAS#: 2576-92-3

Chemical Formula: C13H22ClNO3

Exact Mass: 275.1288

Molecular Weight: 275.77

Elemental Analysis: C, 56.62; H, 8.04; Cl, 12.85; N, 5.08; O, 17.40

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Synonym
Isoetharine hydrochloride
IUPAC/Chemical Name
(R,*)-(1)-4-(1-Hydroxy-2-((1-methylethyl)amino)butyl)pyrocatechol hydrochloride
InChi Key
MUFDLGGSOCHQOC-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H21NO3.ClH/c1-4-10(14-8(2)3)13(17)9-5-6-11(15)12(16)7-9;/h5-8,10,13-17H,4H2,1-3H3;1H
SMILES Code
OC1=CC=C(C(C(NC(C)C)CC)O)C=C1O.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 275.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li T, Cao J, Li Z, Wang X, He P. Broad screening and identification of β-agonists in feed and animal body fluid and tissues using ultra-high performance liquid chromatography-quadrupole-orbitrap high resolution mass spectrometry combined with spectra library search. Food Chem. 2016 Feb 1;192:188-96. doi: 10.1016/j.foodchem.2015.06.104. Epub 2015 Jun 30. PubMed PMID: 26304337. 2: Charan NB, Johnson SR, Lakshminarayan S, Thompson WH, Carvalho P. Nitric oxide and beta-adrenergic agonist-induced bronchial arterial vasodilation. J Appl Physiol (1985). 1997 Feb;82(2):686-92. PubMed PMID: 9049753. 3: Newcomb RW. Use of adrenergic bronchodilators by pediatric allergists and pulmonologists. Am J Dis Child. 1989 Apr;143(4):481-5. PubMed PMID: 2929531. 4: Das Gupta V, Parasrampuria J, Gardner SN. Chemical stabilities of isoetharine hydrochloride, metaproterenol sulphate and terbutaline sulphate after mixing with normal saline for respiratory therapy. J Clin Pharm Ther. 1988 Apr;13(2):165-9. PubMed PMID: 3392129. 5: König P, Hurst DJ. Nebulized isoetharine and fenoterol in acute attacks of asthma. Arch Intern Med. 1983 Jul;143(7):1361-4. PubMed PMID: 6347110. 6: Park GB, Koss RF, Utter J, Mayes BA, Edelson J. Determination of isoetharine in plasma by reversed-phase chromatography with amperometric detection. J Pharm Sci. 1982 Aug;71(8):932-4. PubMed PMID: 7120101. 7: Hunke WA, Katz E, Gorman WG. Stability of some bronchodilator solutions during ultrasonic nebulization. Am J Hosp Pharm. 1982 Feb;39(2):297-300. PubMed PMID: 7058801. 8: Kleinberg ML, Stauffer GL, Latiolais CJ. Stability of five liquid drug products after unit dose repackaging. Am J Hosp Pharm. 1980 May;37(5):680-2. PubMed PMID: 7386479. 9: Schwartz AL, Lipton JM, Warburton D, Johnson LB, Twarog FJ. Management of acute asthma in childhood. A randomized evaluation of beta-adrenergic agents. Am J Dis Child. 1980 May;134(5):474-8. PubMed PMID: 6990745. 10: Spector SL, Hudson L, Petty TL. Effect of bronkosol and its components on cardiopulmonary parameters in asthmatic patients. J Allergy Clin Immunol. 1977 May;59(5):371-6. PubMed PMID: 323326. 11: Unger DL, Unger L. Isoetharine methanesulfonate with phenylephrine hydrochloride and thenyldiamine (Bronkometer) in hypertensive and sympathomimetic amine-sensitive asthmatic patients. Dis Chest. 1967 Feb;51(2):153-5. PubMed PMID: 4381226.