2-Iodomelatonin | CAS#93515-00-5 | MT1 agonist

MedKoo Cat#: 462451 | Name: 2-Iodomelatonin

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

2-Iodomelatonin is a synthetic iodinated analog of melatonin that acts as a high-affinity agonist at melatonin receptors MT₁ and MT₂, with enhanced receptor binding compared to native melatonin. It exhibits bioactivity in regulating circadian rhythms, sleep, and thermoregulation, making it useful in neuroendocrine and chronobiology research. Its mechanism of action involves activation of G-protein-coupled melatonin receptors in the suprachiasmatic nucleus (SCN), leading to downstream modulation of cyclic AMP and other intracellular signaling pathways.

Chemical Structure

2-Iodomelatonin

CAS#93515-00-5

Theoretical Analysis

MedKoo Cat#: 462451

Name: 2-Iodomelatonin

CAS#: 93515-00-5

Chemical Formula: C13H15IN2O2

Exact Mass: 358.0178

Molecular Weight: 358.18

Elemental Analysis: C, 43.59; H, 4.22; I, 35.43; N, 7.82; O, 8.93

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 350.00	2 Weeks
25mg	USD 550.00	2 Weeks

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Related CAS #

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Synonym

2-Iodomelatonin

IUPAC/Chemical Name

N-(2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl)acetamide

InChi Key

FJDDSMSDZHURBJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H15IN2O2/c1-8(17)15-6-5-10-11-7-9(18-2)3-4-12(11)16-13(10)14/h3-4,7,16H,5-6H2,1-2H3,(H,15,17)

SMILES Code

CC(NCCC1=C(I)NC2=C1C=C(OC)C=C2)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 358.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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