MedKoo Cat#: 573516 | Name: Raubasine hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Raubasine hydrochloride, also known as Ajmalicine HCl, is an antihypertensive drug used in the treatment of high blood pressure. It acts as an α1-adrenergic receptor antagonist with preferential actions over α2-adrenergic receptors, underlying its hypotensive rather than hypertensive effects.

Chemical Structure

Raubasine hydrochloride
Raubasine hydrochloride
CAS#4373-34-6

Theoretical Analysis

MedKoo Cat#: 573516

Name: Raubasine hydrochloride

CAS#: 4373-34-6

Chemical Formula: C21H25ClN2O3

Exact Mass: 388.1554

Molecular Weight: 388.89

Elemental Analysis: C, 64.86; H, 6.48; Cl, 9.12; N, 7.20; O, 12.34

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
δ-yohimbine, Ajmalicine, Card-Lamuran, Circolene, Cristanyl, Duxil, Duxor, gamma-Yohimbin hydrochloride, Hydroxysarpon, Iskedyl, Isosarpan, Isquebral, Lamuran, Melanex, Raubasine hydrochloride, Raubasine HCl, Raunatin, Saltucin Co, Salvalion, Sarpan
IUPAC/Chemical Name
Oxayohimban-16-carboxylic acid, 16,17-didehydro-19-methyl-, methyl ester, monohydrochloride
InChi Key
YWPZOTNKHMBWPD-QAWKRFFXSA-N
InChi Code
1S/C21H24N2O3.ClH/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2;/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3;1H/t12-,15-,16+,19-;/m0./s1
SMILES Code
c12ccccc2c2c([nH]1)[C@@H]1C[C@H]3[C@H](C[N@@]1CC2)[C@@H](OC=C3C(OC)=O)C.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 388.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Demichel P, Gomond P, Roquebert J. alpha-Adrenoceptor blocking properties of raubasine in pithed rats. Br J Pharmacol. 1982 Nov;77(3):449-54. PubMed PMID: 6128043; PubMed Central PMCID: PMC2044614. 2: Demichel P, Gomond P, Roquebert J. Pre- and postsynaptic alpha-adrenoceptor blocking activity of raubasine in the rat vas deferens. Br J Pharmacol. 1981 Dec;74(4):739-45. PubMed PMID: 6118191; PubMed Central PMCID: PMC2071904.