2',2'-Difluoro-2'-deoxyuridine | CAS#114248-23-6 | active metabolite

MedKoo Cat#: 462417 | Name: 2',2'-Difluoro-2'-deoxyuridine

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

2',2'-Difluoro-2'-deoxyuridine is an active metabolite of the anticancer nucleoside analog gemcitabine.

Chemical Structure

2',2'-Difluoro-2'-deoxyuridine

CAS#114248-23-6

Theoretical Analysis

MedKoo Cat#: 462417

Name: 2',2'-Difluoro-2'-deoxyuridine

CAS#: 114248-23-6

Chemical Formula: C9H10F2N2O5

Exact Mass: 264.0558

Molecular Weight: 264.18

Elemental Analysis: C, 40.92; H, 3.82; F, 14.38; N, 10.60; O, 30.28

Price and Availability

Size	Price	Availability	Quantity
250mg	USD 350.00	2 Weeks
1g	USD 750.00	2 Weeks

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Related CAS #

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Synonym

2',2'-Difluoro-2'-deoxyuridine; dFdU;

IUPAC/Chemical Name

2′-deoxy-2′,2′-difluoro-uridine

InChi Key

FIRDBEQIJQERSE-QPPQHZFASA-N

InChi Code

InChI=1S/C9H10F2N2O5/c10-9(11)6(16)4(3-14)18-7(9)13-2-1-5(15)12-8(13)17/h1-2,4,6-7,14,16H,3H2,(H,12,15,17)/t4-,6-,7-/m1/s1

SMILES Code

O=C(N(C=C1)[C@H]2C(F)(F)[C@H](O)[C@@H](CO)O2)NC1=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 264.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Veltkamp, S.A., Pluim, D., van Eijndhoven, M.A.J., et al. New insights into the pharmacology and cytotoxicity of gemcitabine and 2',2'-difluorodeoxyuridine. Mol. Cancer Ther. 7(8), 2415-2425 (2008). 2: Pauwels, B., Korst, A.E.C., Lambrechts, H.A.J., et al. The radiosensitising effect of difluorodeoxyuridine, a metabolite of gemcitabine, in vitro. Cancer Chemother. Pharmacol. 58(2), 219-228 (2006).