MedKoo Cat#: 462410 | Name: AMG 925 HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

AMG 925 HCl is a potent, selective, and orally available FLT3/CDK4 dual inhibitor.

Chemical Structure

AMG 925 HCl
AMG 925 HCl
CAS#1401034-19-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 462410

Name: AMG 925 HCl

CAS#: 1401034-19-2 (HCl)

Chemical Formula: C26H30ClN7O2

Exact Mass: 507.2150

Molecular Weight: 508.02

Elemental Analysis: C, 61.47; H, 5.95; Cl, 6.98; N, 19.30; O, 6.30

Price and Availability

Size Price Availability Quantity
5mg USD 285.00 Back order
10mg USD 520.00 Back order
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Synonym
AMG 925 HCl; AMG925 HCl; AMG-925 HCl
IUPAC/Chemical Name
2-hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethan-1-one hydrochloride
InChi Key
JJDSFFVYZSLRLY-AELULUIVSA-N
InChi Code
InChI=1S/C26H29N7O2.ClH/c1-16-2-5-18(6-3-16)33-22-13-27-10-8-19(22)20-12-28-26(31-25(20)33)30-23-7-4-17-14-32(24(35)15-34)11-9-21(17)29-23;/h4,7-8,10,12-13,16,18,34H,2-3,5-6,9,11,14-15H2,1H3,(H,28,29,30,31);1H/t16-,18-;
SMILES Code
OCC(N1CC2=C(N=C(NC3=NC=C4C(N([C@H]5CC[C@H](C)CC5)C6=CN=CC=C64)=N3)C=C2)CC1)=O.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 508.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Keegan K, Li C, Li Z, et al. Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor for treating acute myeloid leukemia. Mol Cancer Ther. 2014;13(4):880-889. doi:10.1158/1535-7163.MCT-13-0858