MedKoo Cat#: 462407 | Name: 4-​Bromo A23187
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

4-Bromo A23187 is a halogenated analog of the highly selective calcium ionophore A-23187. It is a calcium modulator that induces apoptosis in different cells, including HL-60 cells.

Chemical Structure

4-​Bromo A23187
4-​Bromo A23187
CAS#76455-48-6 (bromo)

Theoretical Analysis

MedKoo Cat#: 462407

Name: 4-​Bromo A23187

CAS#: 76455-48-6 (bromo)

Chemical Formula: C29H36BrN3O6

Exact Mass: 601.1787

Molecular Weight: 602.53

Elemental Analysis: C, 57.81; H, 6.02; Br, 13.26; N, 6.97; O, 15.93

Price and Availability

Size Price Availability Quantity
1mg USD 350.00 2 Weeks
5mg USD 950.00 2 Weeks
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Synonym
4-​Bromo A23187; 4-​Bromo A-23187; 4-​Bromo A 23187; 4-Bromocalcimycin; 4-bromo-Calcium Ionophore A23187
IUPAC/Chemical Name
6-bromo-5-(methylamino)-2-[[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid
InChi Key
LDXQFZZGVTWFCF-FHYGWRBKSA-N
InChi Code
InChI=1S/C29H36BrN3O6/c1-14-8-9-29(16(3)11-15(2)27(39-29)17(4)26(34)19-7-6-10-32-19)38-20(14)13-22-33-25-21(37-22)12-18(30)24(31-5)23(25)28(35)36/h6-7,10,12,14-17,20,27,31-32H,8-9,11,13H2,1-5H3,(H,35,36)/t14-,15-,16-,17-,20-,27+,29+/m1/s1
SMILES Code
O=C(C1=C2N=C(C[C@H]3O[C@]4(O[C@H]([C@H](C)C(C5=CC=CN5)=O)[C@H](C)C[C@H]4C)CC[C@H]3C)OC2=CC(Br)=C1NC)O
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 602.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhu WH, Loh TT. Roles of calcium in the regulation of apoptosis in HL-60 promyelocytic leukemia cells. Life Sci. 1995;57(23):2091-2099. doi:10.1016/0024-3205(95)02202-t